Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.65 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.63 |
| ▸ | MMP2 | P08253 | 2/20 | 0.59 |
| ▸ | MMP1 | P03956 | 2/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.59 |
| ▸ | CA2 | P00918 | 1/20 | 0.59 |
| ▸ | MMP9 | P14780 | 1/20 | 0.59 |
| ▸ | MMP8 | P22894 | 1/20 | 0.59 |
| ▸ | MMP13 | P45452 | 1/20 | 0.59 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | FLT1 | P17948 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16540405 | 0.95 | EGFR (0.60) | EGFRERBB2MMP2MMP1CA1 | |
| SCHEMBL28403383 | 0.87 | EGFR (0.65) | EGFRERBB2MMP2MMP1CA1 | |
| SCHEMBL8057333 | 0.85 | EGFR (0.66) | EGFRERBB2MMP2MMP1CA1 | |
| SCHEMBL3928427 | 0.85 | EGFR (0.63) | EGFRERBB2MMP2MMP1CA1 | |
| SCHEMBL7749432 | 0.83 | MMP2 (0.59) | EGFRERBB2MMP2MMP1CA1 | |
| SCHEMBL26041453 | 0.81 | EGFR (0.61) | EGFRERBB2MMP2MMP1CA1 | |
| SCHEMBL7776386 | 0.81 | MMP2 (0.65) | EGFRERBB2MMP2MMP1CA1 | |
| SCHEMBL6102084 | 0.81 | HSD17B10 (0.73) | EGFRERBB2MMP2MMP1CA1 | |
| SCHEMBL7969578 | 0.81 | EGFR (0.60) | EGFRERBB2MMP2MMP1CA1 | |
| SCHEMBL26282718 | 0.81 | MMP2 (0.65) | EGFRERBB2MMP2MMP1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007139856-A2 | HETEROBICYCLIC METALLOPROTEASE INHIBITORS | ALANTOS PHARMACEUTICALS, INC. (US) | 2007-12-06 | — | — | WO | disclosed |