Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 9/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | CASP1 | P29466 | 3/20 | 0.34 |
| ▸ | CASP7 | P55210 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.32 |
| ▸ | PDE4A | P27815 | 6/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27337722 | 0.99 | PDE10A (0.47) | PDE10AALDH1A1CYP1A2CASP1CASP7 | |
| SCHEMBL6156828 | 0.93 | PDE10A (0.45) | PDE10AALDH1A1CYP1A2CYP2C9CHRM3 | |
| Hydrochloric Acid SCHEMBL27332647 | 0.92 | PDE10A (0.44) | PDE10AALDH1A1CYP1A2CYP2C9CHRM3 | |
| SCHEMBL5964670 | 0.72 | PDE10A (0.46) | PDE10ACHRM3PDE4APDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL7326791 | 0.71 | PDE10A (0.45) | PDE10ACHRM3PDE4APDE4BPDE4C | |
| SCHEMBL8978388 | 0.71 | ALDH1A1 (0.37) | PDE10AALDH1A1CYP1A2CASP1CASP7 | |
| Hydrochloric Acid SCHEMBL27338760 | 0.70 | ALDH1A1 (0.37) | PDE10AALDH1A1CYP1A2CASP1CASP7 | |
| SCHEMBL1388150 | 0.70 | PDE10A (0.44) | PDE10ACHRM3PDE4APDE4BPDE4C | |
| SCHEMBL1388397 | 0.69 | PDE10A (0.43) | PDE10ACHRM3PDE4APDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL7022609 | 0.69 | PDE10A (0.43) | PDE10ACHRM3PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0912575-A4 | IMPROVED METHODS FOR THE SYNTHESIS OF CHEMICAL COMPOUNDS HAVING PDE-IV INHIBITORY ACTIVITY | EURO CELTIQUE SA (LU) | 2001-04-25 | — | — | EP | claimed |
| CN-1045778-C | Novel chemical compounds having PDE-IV inhibition activity | EURO CELTIQUE SA (LU) | 1999-10-20 | — | — | CN | claimed |
| EP-0912575-A1 | IMPROVED METHODS FOR THE SYNTHESIS OF CHEMICAL COMPOUNDS HAVING PDE-IV INHIBITORY ACTIVITY | Euro-Celtique S.A. (LU) | 1999-05-06 | — | — | EP | claimed |
| WO-1997046561-A1 | IMPROVED METHODS FOR THE SYNTHESIS OF CHEMICAL COMPOUNDS HAVING PDE-IV INHIBITORY ACTIVITY | EURO-CELTIQUE, S.A. (LU) | 1997-12-11 | — | — | WO | claimed |
| CN-1125445-A | Novel compounds having P.DE-IV inhibitory activity | EURO CELTIQUE SA (LU) | 1996-06-26 | — | — | CN | claimed |
| CN-1377353-A | Purine derivatives having phosphodiesterase IN inhibition activity | EURO CELTIQUE SA (LU) | 2002-10-30 | — | — | CN | disclosed |
| CN-1045778-C | Novel chemical compounds having PDE-IV inhibition activity | EURO CELTIQUE SA (LU) | 1999-10-20 | — | — | CN | disclosed |
| CN-1125445-A | Novel compounds having P.DE-IV inhibitory activity | EURO CELTIQUE SA (LU) | 1996-06-26 | — | — | CN | disclosed |