Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | CPA1 | P15085 | 1/20 | 0.39 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | MMP7 | P09237 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | GCLC | P48506 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.32 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.32 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6172887 | 0.76 | CHRM1 (0.40) | MMEACECPA1ACE2ADAMTS4 | |
| SCHEMBL2435695 | 0.76 | ADAMTS4 (0.42) | MMEACECPA1ACE2ADAMTS4 | |
| SCHEMBL26870066 | 0.75 | GRIA1 (0.31) | — | |
| SCHEMBL2554677 | 0.71 | ALDH1A1 (0.33) | MMP1MMP2MMP3ALDH1A1 | |
| SCHEMBL18047580 | 0.70 | ADAMTS4 (0.44) | MMEACECPA1ACE2ADAMTS4 | |
| SCHEMBL5148621 | 0.70 | ADAMTS4 (0.44) | MMEACECPA1ACE2ADAMTS4 | |
| SCHEMBL697449 | 0.70 | ADAMTS4 (0.44) | MMEACECPA1ACE2ADAMTS4 | |
| SCHEMBL725182 | 0.70 | ADAMTS4 (0.44) | MMEACECPA1ACE2ADAMTS4 | |
| SCHEMBL29633569 | 0.70 | ADAMTS4 (0.44) | MMEACECPA1ACE2ADAMTS4 | |
| SCHEMBL697448 | 0.70 | ADAMTS4 (0.44) | MMEACECPA1ACE2ADAMTS4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0844874-A4 | METHODS AND COMPOSITIONS USEFUL FOR INHIBITION OF ALPHA v BETA 5 MEDIATED ANGIOGENESIS | SCRIPPS RESEARCH INST (US) | 2001-02-14 | — | — | EP | disclosed |
| EP-0844874-A1 | METHODS AND COMPOSITIONS USEFUL FOR INHIBITION OF $g(a) v?$g(b) 5? MEDIATED ANGIOGENESIS | THE SCRIPPS RESEARCH INSTITUTE (US) | 1998-06-03 | — | — | EP | disclosed |
| WO-1997006791-A1 | METHODS AND COMPOSITIONS USEFUL FOR INHIBITION OF αvβ5 MEDIATED ANGIOGENESIS | THE SCRIPPS RESEARCH INSTITUTE (US) | 1997-02-27 | — | — | WO | disclosed |