Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 7/20 | 0.38 |
| ▸ | BCHE | P06276 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7465450 | 0.78 | — | — | |
| SCHEMBL10767417 | 0.76 | HPGD (0.41) | SIGMAR1ACHEBCHEMEN1KMT2A | |
| SCHEMBL15966901 | 0.69 | KDM4E (0.30) | ALDH1A1 | |
| SCHEMBL7466457 | 0.69 | SIGMAR1 (0.38) | SIGMAR1ACHEBCHEMEN1KMT2A | |
| SCHEMBL11683434 | 0.63 | NOS3 (0.41) | SIGMAR1ACHEBCHEMEN1KMT2A | |
| SCHEMBL31183042 | 0.63 | SIGMAR1 (0.39) | SIGMAR1ACHEBCHEMEN1KMT2A | |
| SCHEMBL11497896 | 0.60 | NPC1 (0.42) | SIGMAR1ACHEBCHEMEN1KMT2A | |
| SCHEMBL4573279 | 0.60 | SIGMAR1 (0.42) | SIGMAR1ACHEBCHEMEN1KMT2A | |
| SCHEMBL6801284 | 0.58 | SIGMAR1 (0.44) | SIGMAR1ACHEBCHEMEN1KMT2A | |
| SCHEMBL7114310 | 0.58 | SIGMAR1 (0.44) | SIGMAR1ACHEBCHEMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6111110-A | Synthesis of benzo[f]quinolinones | ELI LILLY AND COMPANY (US) | 2000-08-29 | — | — | US | claimed |
| EP-0969003-A2 | Process for the preparation of benzo[f]quinolinone derivatives and intermediates | ELI LILLY AND COMPANY (US) | 2000-01-05 | — | — | EP | claimed |
| EP-0839807-A1 | Synthesis of benzo(f)quinolinones | ELI LILLY AND COMPANY (US) | 1998-05-06 | — | — | EP | claimed |
| EP-0969003-A3 | Process for the preparation of benzo[f]quinolinone derivatives and intermediates | ELI LILLY AND COMPANY (US) | 2001-01-10 | — | — | EP | disclosed |
| US-6111110-A | Synthesis of benzo[f]quinolinones | ELI LILLY AND COMPANY (US) | 2000-08-29 | — | — | US | disclosed |
| EP-0969003-A2 | Process for the preparation of benzo[f]quinolinone derivatives and intermediates | ELI LILLY AND COMPANY (US) | 2000-01-05 | — | — | EP | disclosed |
| EP-0969003-A2 | Process for the preparation of benzo[f]quinolinone derivatives and intermediates | ELI LILLY AND COMPANY (US) | 2000-01-05 | — | — | EP | disclosed |
| EP-0839807-A1 | Synthesis of benzo(f)quinolinones | ELI LILLY AND COMPANY (US) | 1998-05-06 | — | — | EP | disclosed |
| EP-0839807-A1 | Synthesis of benzo(f)quinolinones | ELI LILLY AND COMPANY (US) | 1998-05-06 | — | — | EP | disclosed |