Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 7/20 | 0.51 |
| ▸ | SIRT3 | Q9NTG7 | 5/20 | 0.51 |
| ▸ | THRA | P10827 | 3/20 | 0.51 |
| ▸ | THRB | P10828 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.51 |
| ▸ | DRD1 | P21728 | 2/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.51 |
| ▸ | DRD3 | P35462 | 2/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.51 |
| ▸ | KDM7A | Q6ZMT4 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7750214 | 0.86 | EYA3 (0.66) | KDM5ASIRT3THRATHRBALDH1A1 | |
| SCHEMBL4588327 | 0.86 | SIRT3 (0.68) | KDM5ASIRT3THRATHRBALDH1A1 | |
| Hydrochloric Acid SCHEMBL10614888 | 0.85 | ALDH1A1 (0.69) | KDM5ASIRT3THRATHRBALDH1A1 | |
| SCHEMBL7079994 | 0.85 | SIRT3 (0.73) | KDM5ASIRT3THRATHRBALDH1A1 | |
| SCHEMBL13654920 | 0.77 | EYA3 (0.67) | KDM5ASIRT3THRATHRBALDH1A1 | |
| SCHEMBL3128930 | 0.76 | SIRT3 (0.61) | KDM5ASIRT3THRATHRBALDH1A1 | |
| Budiodarone SCHEMBL3123242 | 0.76 | SIRT3 (0.70) | KDM5ASIRT3THRATHRBALDH1A1 | |
| SCHEMBL3128944 | 0.76 | SIRT3 (0.61) | KDM5ASIRT3THRATHRBALDH1A1 | |
| Budiodarone SCHEMBL1946426 | 0.76 | SIRT3 (0.70) | KDM5ASIRT3THRATHRBALDH1A1 | |
| Budiodarone SCHEMBL29380098 | 0.76 | SIRT3 (0.70) | KDM5ASIRT3THRATHRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316487-B1 | FOR THERAPY OF VENTRICULAR TACHYARRHYTHMIAS, ESPECIALLY IN PATIENTS WITH CONGESTIVE HEART FAILURE AND VENTRICULAR ARRHYTHMIAS AND SUPRAVENTRICULAR ARRHYTHMIAS, INCLUDING ATRIAL FIBRILLATION AND RE-ENTRANT TACHYARRHYTHMIAS | ARYX THERAPEUTICS | 2001-11-13 | — | — | US | disclosed |