⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL806271 | 0.92 | — | — | |
| SCHEMBL17258247 | 0.90 | GPR84 (0.50) | — | |
| SCHEMBL8458271 | 0.90 | GPR84 (0.50) | — | |
| SCHEMBL21341927 | 0.90 | GPR84 (0.50) | — | |
| SCHEMBL8459215 | 0.90 | GPR84 (0.50) | — | |
| SCHEMBL16203505 | 0.90 | GPR84 (0.50) | — | |
| SCHEMBL6539565 | 0.90 | GPR84 (0.50) | — | |
| SCHEMBL20651364 | 0.90 | GPR84 (0.50) | — | |
| SCHEMBL12445944 | 0.85 | LMNA (0.43) | — | |
| SCHEMBL5909180 | 0.85 | LMNA (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 306 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119350214-A | Method for synthesizing NMP by heat coupling and sectional reaction and application thereof | 滨州裕能电子材料股份有限公司 | 2025-01-24 | — | — | CN | claimed |
| WO-2024147636-A1 | METHOD FOR PRODUCING N-METHYL-2-PYRROLIDONE USING POLYHYDROXYALKANOATE, AND N-METHYL-2-PYRROLIDONE PREPARED THEREFROM | 씨제이제일제당(주) | 2024-07-11 | — | — | WO | claimed |
| CN-116178236-A | Preparation method of N-methyl pyrrolidone | 万华化学集团股份有限公司 | 2023-05-30 | — | — | CN | claimed |
| CN-116178237-A | Method for preparing N-methyl pyrrolidone | 万华化学集团股份有限公司 | 2023-05-30 | — | — | CN | claimed |
| CN-214051662-U | U-shaped pipeline reactor for promoting generation of intermediate | 四川天华富邦化工有限责任公司 | 2021-08-27 | — | — | CN | claimed |
| EP-3774750-A1 | IMMUNOMODULATORS, COMPOSITIONS AND METHODS THEREOF | Betta Pharmaceuticals Co., Ltd (CN) | 2021-02-17 | — | — | EP | claimed |
| CN-107624113-B | Tetrahydropyridopyrimidines and tetrahydropyridopyridines as inhibitors of HBsAg (HBV surface antigen) and HBV DNA production for the treatment of hepatitis B virus infection | 豪夫迈·罗氏有限公司 | 2020-10-23 | — | — | CN | claimed |
| WO-2019192506-A1 | IMMUNOMODULATORS, COMPOSITIONS AND METHODS THEREOF | BETTA PHARMACEUTICALS CO., LTD (CN) | 2019-10-10 | — | — | WO | claimed |
| EP-3292120-B1 | TETRAHYDROPYRIDOPYRIMIDINES AND TETRAHYDROPYRIDOPYRIDINES AS INHIBITORS OF HBSAG (HBV SURFACE ANTIGEN) AND HBV DNA PRODUCTION FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTIONS | HOFFMANN LA ROCHE (CH) | 2019-06-19 | — | — | EP | claimed |
| CN-108290889-A | Novel piperazine and piperidine derivatives, their synthesis and their use in inhibiting VDAC oligomerization, apoptosis and mitochondrial dysfunction | 内盖夫国家生物技术研究所 | 2018-07-17 | — | — | CN | claimed |
| EP-3292120-A1 | TETRAHYDROPYRIDOPYRIMIDINES AND TETRAHYDROPYRIDOPYRIDINES AS INHIBITORS OF HBSAG (HBV SURFACE ANTIGEN) AND HBV DNA PRODUCTION FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTIONS | H. Hoffnabb-La Roche Ag (CH) | 2018-03-14 | — | — | EP | claimed |
| US-9845322-B2 | Tetrahydropyridopyrimidines and tetrahydropyridopyridines for the treatment and prophylaxis of hepatitis B virus infection | HOFFMANN-LA ROCHE INC. (US) | 2017-12-19 | — | — | US | claimed |
| WO-2016177655-A1 | TETRAHYDROPYRIDOPYRIMIDINES AND TETRAHYDROPYRIDOPYRIDINES AS INHIBITORS OF HBSAG (HBV SURFACE ANTIGEN) AND HBV DNA PRODUCTION FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTIONS | F. HOFFMANN-LA ROCHE AG (CH) | 2016-11-10 | — | — | WO | claimed |
| US-20160326167-A1 | Novel Tetrahydropyridopyrimidines and Tetrahydropyridopyridines for the Treatment and Prophylaxis of Hepatitis B Virus Infection | HOFFMANN-LA ROCHE INC. (US) | 2016-11-10 | — | — | US | claimed |
| US-8519157-B2 | Method for producing of ultra-clean and high-purity N-methyl pyrrolidone | SHANGHAI CHEMICAL REAGENT RESEARCH INSTITUTE (CN) | 2013-08-27 | — | — | US | claimed |
| WO-2003051813-A1 | METHODS OF MAKING INTERMEDIATES FROM POLYHYDROXYALKANOATES | METABOLIX, INC. (US) | 2003-06-26 | — | — | WO | claimed |
| EP-4688789-A1 | MACROCYCLIC RAS INHIBITORS | Revolution Medicines, Inc. (US) | 2026-02-11 | — | — | EP | disclosed |
| US-12544421-B2 | VDAC inhibitors for treating inflammatory bowel diseases | The National Institute for Biotechnology in the Negev Ltd. (IL) | 2026-02-10 | — | — | US | disclosed |
| EP-0200915-A1 | Aminopropanol derivatives, process for their preparation, their use and medicines containing them | Roche Diagnostics GmbH (DE) | 1986-11-12 | — | — | EP | disclosed |
| EP-0186817-A1 | 3(2H)pyridazinone, process for its preparation and anti-allergic agent containing it | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1986-07-09 | — | — | EP | disclosed |