SCHEMBL7753495

SCHEMBL7753495

COc1ccc2c(N3CCN(CCCC(=O)c4ccc(F)cc4)CC3)noc2c1

nearest known ligand 0.72

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.55
POLB P06746 1/20 0.55
DRD2 P14416 6/20 0.54
DRD4 P21917 4/20 0.54
SIGMAR1 Q99720 1/20 0.54
HTR2A P28223 3/20 0.54
HTR2C P28335 2/20 0.54
DRD3 P35462 6/20 0.52
TSHR P16473 1/20 0.51
HTR1A P08908 1/20 0.51
ADRA2C P18825 1/20 0.51
HRH1 P35367 1/20 0.51
HTR7 P34969 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7754509 0.87 DRD2 (0.54) DRD2DRD4SIGMAR1HTR2AHTR2C
SCHEMBL7753532 0.87 DRD2 (0.49) ALDH1A1POLBDRD2DRD4SIGMAR1
SCHEMBL7749831 0.87 DRD2 (0.49) ALDH1A1POLBDRD2DRD4SIGMAR1
SCHEMBL7753517 0.87 DRD2 (0.49) ALDH1A1POLBDRD2DRD4SIGMAR1
Bromide SCHEMBL7754529 0.86 DRD2 (0.53) DRD2DRD4SIGMAR1HTR2AHTR2C
Hydrochloric Acid SCHEMBL7755991 0.86 TSHR (0.54) DRD2DRD4SIGMAR1HTR2AHTR2C
SCHEMBL7753505 0.85 DRD2 (0.46) DRD2DRD4SIGMAR1HTR2AHTR2C
SCHEMBL7754671 0.85 HTR1A (0.45) DRD2DRD4SIGMAR1HTR2AHTR2C
SCHEMBL7755965 0.84 DRD2 (0.56) DRD2DRD4SIGMAR1HTR2AHTR2C
SCHEMBL7754653 0.84 DRD2 (0.47) DRD2DRD4SIGMAR1HTR2ADRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0833820-B1 BENZISOXAZOLE AND INDAZOLE DERIVATIVES AS ANTIPSYCHOTIC AGENTS AVENTIS PHARMA INC (US) 2001-02-14 EP disclosed
US-6008348-A TREATING A 1-TOSYLATED INDAZOL-3-YL PIPERAZINE DERIVATIVE WITH CONCENTRATED HYDROCHLORIC ACID TO PRODUCE THE DETOSYLATED INDAZOL-3-YL PIPERAZINE COMPOUND OF GIVEN FORMULA HOECHST MARION ROUSSEL, INC. (US) 1999-12-28 US disclosed
US-5965554-A PIPERAZINYLBENZISOXAZOLE DERIVATIVES HOECHST MARION ROUSSEL, INC. (US) 1999-10-12 US disclosed
EP-0833820-A1 BENZISOXAZOLE AND INDAZOLE DERIVATIVES AS ANTIPSYCHOTIC AGENTS HOECHST MARION ROUSSEL, INC. (US) 1998-04-08 EP disclosed
WO-1996039397-A1 BENZISOXAZOLE AND INDAZOLE DERIVATIVES AS ANTIPSYCHOTIC AGENTS HOECHST MARION ROUSSEL, INC. (US) 1996-12-12 WO disclosed