Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.38 |
| ▸ | NAALAD2 | Q9Y3Q0 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2081023 | 0.84 | CYP2C9 (0.46) | MMEPOLBNOD1TGFBR1KDM4E | |
| SCHEMBL1912625 | 0.84 | CYP2C9 (0.46) | MMEPOLBNOD1TGFBR1KDM4E | |
| SCHEMBL1995530 | 0.81 | TGFBR1 (0.56) | MMETGFBR1KDM4EMAPTTHRB | |
| SCHEMBL4812263 | 0.81 | TGFBR1 (0.56) | MMETGFBR1KDM4EMAPTTHRB | |
| SCHEMBL1995531 | 0.81 | TGFBR1 (0.56) | MMETGFBR1KDM4EMAPTTHRB | |
| SCHEMBL1133639 | 0.80 | POLB (0.40) | MMEPOLBNOD1TGFBR1KDM4E | |
| SCHEMBL15623817 | 0.80 | NOD1 (0.61) | NOD1MEN1KMT2A | |
| SCHEMBL2953242 | 0.80 | POLB (0.40) | MMEPOLBNOD1TGFBR1KDM4E | |
| SCHEMBL8468722 | 0.80 | POLB (0.40) | MMEPOLBNOD1TGFBR1KDM4E | |
| SCHEMBL974815 | 0.80 | NOD1 (0.51) | POLBNOD1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1069906-A1 | CONJUGATES USEFUL IN THE TREATMENT OF PROSTRATE CANCER | Merck & Co., Inc. (US) | 2001-01-24 | — | — | EP | claimed |
| WO-1999044628-A1 | CONJUGATES USEFUL IN THE TREATMENT OF PROSTATE CANCER | MERCK & CO., INC. (US) | 1999-09-10 | — | — | WO | claimed |
| CN-1181092-C | Conjugates useful in treatment of prostate cancer | — | 2004-12-22 | — | — | CN | disclosed |