Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 3/20 | 0.46 |
| ▸ | ADK | P55263 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CCKAR | P32238 | 1/20 | 0.43 |
| ▸ | CCKBR | P32239 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8560971 | 0.80 | CCKBR (0.50) | CMA1GSK3BADKL3MBTL1GSK3A | |
| SCHEMBL3173671 | 0.77 | GSK3B (0.52) | CMA1GSK3BADKL3MBTL1GSK3A | |
| SCHEMBL4422395 | 0.77 | GSK3B (0.52) | CMA1GSK3BADKL3MBTL1GSK3A | |
| SCHEMBL4429210 | 0.77 | GSK3B (0.52) | CMA1GSK3BADKL3MBTL1GSK3A | |
| SCHEMBL8559078 | 0.77 | BACE1 (0.50) | CMA1GSK3BADKL3MBTL1CCKBR | |
| SCHEMBL7751752 | 0.76 | CCKAR (0.70) | CCKARCCKBR | |
| Hydrochloric Acid SCHEMBL3854466 | 0.76 | GSK3B (0.51) | CMA1GSK3BADKL3MBTL1GSK3A | |
| SCHEMBL7041976 | 0.76 | CCKBR (0.50) | MEN1KMT2ACCKARCCKBR | |
| SCHEMBL4424441 | 0.76 | GAA (0.46) | L3MBTL1POLBMEN1KMT2AGAA | |
| SCHEMBL8638401 | 0.75 | CCKBR (0.59) | GSK3BL3MBTL1GSK3ACASP3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0694039-B1 | 1,5-BENZODIAZEPINE DERIVATIVES HAVING CCK ANTAGONISTIC AND OR AGONISTIC ACTIVITY | GLAXO WELLCOME INC (US) | 2001-01-24 | — | — | EP | disclosed |
| US-5646140-A | CHOLECYSTOKININ ANTAGONIST; APETITE CONTROL | GLAXO WELLCOME INC. (US) | 1997-07-08 | — | — | US | disclosed |
| WO-1994024149-A1 | 1,5-BENZODIAZEPINE DERIVATIVES HAVING CCK ANTAGONISTIC OR AGONISTIC ACTIVITY | GLAXO INC. (US) | 1994-10-27 | — | — | WO | disclosed |