Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.58 |
| ▸ | PPARA | Q07869 | 4/20 | 0.58 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.49 |
| ▸ | MME | P08473 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11480662 | 0.81 | PPARA (0.65) | PPARGPPARACA1CA2MMP2 | |
| SCHEMBL27481969 | 0.81 | PPARG (0.47) | PPARGPPARAFFAR1CA1CA2 | |
| SCHEMBL7929513 | 0.80 | KMT2A (0.49) | FFAR1KMT2AMEN1 | |
| SCHEMBL2317601 | 0.80 | KMT2A (0.49) | FFAR1KMT2AMEN1 | |
| SCHEMBL6824207 | 0.80 | KMT2A (0.49) | FFAR1KMT2AMEN1 | |
| SCHEMBL27884800 | 0.78 | MEN1 (0.50) | PPARGPPARAKMT2AMEN1MAPT | |
| SCHEMBL27884796 | 0.78 | PPARG (0.47) | PPARGPPARAFFAR1CA1CA2 | |
| SCHEMBL11500191 | 0.76 | PPARA (0.79) | PPARGPPARAFFAR1MMP2 | |
| SCHEMBL20045400 | 0.76 | PPARG (0.57) | PPARGPPARAFFAR1CA1CA2 | |
| SCHEMBL21991984 | 0.75 | FFAR1 (0.62) | PPARGPPARAFFAR1MAOBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1083891-A1 | COMPOUNDS WHICH INTERACT WITH THE THYROID HORMONE RECEPTOR FOR THE TREATMENT OF FIBROTIC DISEASE | Arthromics PLC (GB) | 2001-03-21 | — | — | EP | disclosed |
| WO-1999062507-A1 | COMPOUNDS WHICH INTERACT WITH THE THYROID HORMONE RECEPTOR FOR THE TREATMENT OF FIBROTIC DISEASE | ARTHROMICS PLC (GB) | 1999-12-09 | — | — | WO | disclosed |