Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.49 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.49 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | CPA1 | P15085 | 2/20 | 0.46 |
| ▸ | CPB1 | P15086 | 1/20 | 0.46 |
| ▸ | CPA3 | P15088 | 1/20 | 0.46 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6824207 | 1.00 | KMT2A (0.49) | KMT2ASLC1A3SLC1A2SLC1A1MEN1 | |
| SCHEMBL7929513 | 1.00 | KMT2A (0.49) | KMT2ASLC1A3SLC1A2SLC1A1MEN1 | |
| SCHEMBL34471031 | 0.91 | TSHR (0.45) | KMT2ASLC1A3SLC1A2SLC1A1MEN1 | |
| SCHEMBL2312535 | 0.87 | ALDH1A1 (0.52) | KMT2ASLC1A3SLC1A2SLC1A1MEN1 | |
| SCHEMBL21536617 | 0.87 | ALDH1A1 (0.52) | KMT2ASLC1A3SLC1A2SLC1A1MEN1 | |
| SCHEMBL18112934 | 0.86 | SLC1A3 (0.44) | KMT2ASLC1A3SLC1A2SLC1A1MEN1 | |
| SCHEMBL20581847 | 0.86 | ALDH1A1 (0.50) | KMT2ASLC1A3SLC1A2SLC1A1MEN1 | |
| SCHEMBL7507596 | 0.86 | ALDH1A1 (0.50) | KMT2ASLC1A3SLC1A2SLC1A1MEN1 | |
| SCHEMBL29259157 | 0.85 | HTT (0.44) | ALDH1A1CPA1CPB1CPA3CPB2 | |
| SCHEMBL24335280 | 0.84 | MMP1 (0.48) | KMT2ASLC1A3SLC1A2SLC1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102177137-B | 1-phenylpyrrole compounds | EXELIXIS INC | 2015-03-18 | — | — | CN | disclosed |
| US-8642640-B2 | 1-phenylpyrrole derivatives | EXELIXIS, INC. (US) | 2014-02-04 | — | — | US | disclosed |
| EP-2349996-B1 | 1-PHENYLPYRROLE COMPOUNDS | EXELIXIS INC (US) | 2014-01-01 | — | — | EP | disclosed |
| US-20110263544-A1 | 1-Phenylpyrrole Derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2011-10-27 | — | — | US | disclosed |
| CN-102177137-A | 1-phenylpyrrole compounds | EXELIXIS INC | 2011-09-07 | — | — | CN | disclosed |
| EP-2349996-A1 | 1-PHENYLPYRROLE COMPOUNDS | Exelixis, Inc. (US) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010042626-A1 | 1-PHENYLPYRROLE COMPOUNDS | EXELIXIS, INC. (US) | 2010-04-15 | — | — | WO | disclosed |
| US-6306828-B1 | ENTERIC OR PARENTAL SOLUTION OF ALPHA-AND/OR BETA-D-GLUCOPYRANOSYL C2-C20 ALKANOATE; WOUND HEALING AGENTS; DIETETICS; TRAUMAS, METABOLIC DISORDERS | BAXTER INTERNATIONAL, INC. | 2001-10-23 | — | — | US | disclosed |
| EP-0736256-B1 | Enantiomerically-enhanced nutritional energy substrates | BAXTER INT (US) | 1999-06-23 | — | — | EP | disclosed |
| EP-0736256-A1 | Enantiomerically-enhanced nutritional energy substrates | CLINTEC NUTRITION COMPANY (US) | 1996-10-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263544-A1 | 1-Phenylpyrrole Derivatives | REN, AGTR1, NR3C2 | KMT2A 3702/4885SLC1A3 2198/4885SLC1A2 3012/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.