SCHEMBL7754346

SCHEMBL7754346

CC(C)(C)OC(=O)N(CCOCc1ccccc1)CC(N)=O

nearest known ligand 0.56

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 4/20 0.56
HDAC3 O15379 1/20 0.42
HDAC1 Q13547 1/20 0.42
HDAC2 Q92769 1/20 0.42
NCOR2 Q9Y618 1/20 0.42
PPARA Q07869 2/20 0.42
CTSB P07858 2/20 0.41
NPSR1 Q6W5P4 1/20 0.41
ALDH1A1 P00352 1/20 0.38
LMNA P02545 1/20 0.38
HTT P42858 1/20 0.38
PPARG P37231 1/20 0.38
CTSS P25774 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6987866 0.88 L3MBTL1 (0.59) L3MBTL1HDAC3HDAC1HDAC2NCOR2
SCHEMBL4344803 0.85 L3MBTL1 (0.58) L3MBTL1HDAC3HDAC1HDAC2NCOR2
SCHEMBL16772764 0.84 L3MBTL1 (0.57) L3MBTL1HDAC3HDAC1HDAC2NCOR2
SCHEMBL25801927 0.81 L3MBTL1 (0.63) L3MBTL1HDAC3HDAC1HDAC2NCOR2
SCHEMBL16993182 0.80 L3MBTL1 (0.62) L3MBTL1HDAC3HDAC1HDAC2NCOR2
SCHEMBL25250171 0.80 L3MBTL1 (0.61) L3MBTL1HDAC3HDAC1HDAC2NCOR2
SCHEMBL2286496 0.79 L3MBTL1 (0.47) L3MBTL1HDAC3HDAC1HDAC2NCOR2
SCHEMBL25225408 0.79 L3MBTL1 (0.49) L3MBTL1PPARACTSBNPSR1ALDH1A1
SCHEMBL7754342 0.79 L3MBTL1 (0.57) L3MBTL1HDAC3HDAC1HDAC2NCOR2
SCHEMBL4344800 0.78 L3MBTL1 (0.59) L3MBTL1PPARACTSBNPSR1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0767800-B1 HISTIDINE AND HOMOHISTIDINE DERIVATIVES AS INHIBITORS OF PROTEIN FARNESYLTRANSFERASE WARNER LAMBERT CO (US) 2001-03-28 EP disclosed
EP-0767800-A1 HISTIDINE AND HOMOHISTIDINE DERIVATIVES AS INHIBITORS OF PROTEIN FARNESYLTRANSFERASE WARNER-LAMBERT COMPANY (US) 1997-04-16 EP disclosed
US-5571792-A Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase WARNER-LAMBERT COMPANY (US) 1996-11-05 US disclosed
WO-1996000736-A1 HISTIDINE AND HOMOHISTIDINE DERIVATIVES AS INHIBITORS OF PROTEIN FARNESYLTRANSFERASE WARNER-LAMBERT COMPANY (US) 1996-01-11 WO disclosed