Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 18/20 | 0.52 |
| ▸ | PTGES | O14684 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7755348 | 0.90 | SIGMAR1 (0.52) | SIGMAR1PTGESALOX5PPARGPPARD | |
| SCHEMBL7753986 | 0.89 | SIGMAR1 (0.64) | SIGMAR1PTGESALOX5PPARGPPARD | |
| SCHEMBL10771347 | 0.87 | LDHA (0.47) | PPARGPPARDPPARA | |
| SCHEMBL8439902 | 0.87 | SIGMAR1 (0.66) | SIGMAR1PTGESALOX5PPARG | |
| SCHEMBL7755096 | 0.87 | SIGMAR1 (0.58) | SIGMAR1PTGESALOX5PPARG | |
| SCHEMBL7753983 | 0.86 | SIGMAR1 (0.65) | SIGMAR1PTGESALOX5PPARGPPARD | |
| SCHEMBL7753977 | 0.85 | SIGMAR1 (0.67) | SIGMAR1PTGESALOX5PPARG | |
| SCHEMBL7755093 | 0.85 | SIGMAR1 (0.60) | SIGMAR1PTGESALOX5PPARGPPARD | |
| SCHEMBL7755116 | 0.85 | SIGMAR1 (0.58) | SIGMAR1PTGESALOX5PPARG | |
| SCHEMBL7750693 | 0.85 | SIGMAR1 (0.67) | SIGMAR1PTGESALOX5PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0870758-B1 | OPTICALLY ACTIVE SUBSTITUTED PHENYLALKYLAMINE DERIVATIVES | TAISHO PHARMACEUTICAL CO LTD (JP) | 2001-02-21 | — | — | EP | disclosed |
| US-5990151-A | SIGMA 1 RECEPTOR ANTAGOISTS; PSCHOLOGICAL DISORDERS; BRAIN DISORDERS; SCHIZOPHRENIA; ANTIDEPRESSANTS; ANXIOLYTIC AGENTS; ALZHEIMER'S DISEASE; COGNITION ACTIVATORS; HUNTINGTON'S DISEASE; DRUG ABUSE; SIDE EFFECT REDUCTION | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 1999-11-23 | — | — | US | disclosed |
| EP-0870758-A1 | OPTICALLY ACTIVE SUBSTITUTED PHENYLALKYLAMINE DERIVATIVES | TAISHO PHARMACEUTICAL CO. LTD (JP) | 1998-10-14 | — | — | EP | disclosed |