SCHEMBL7754486

SCHEMBL7754486

Cc1c(Br)c(O)cc(Br)c1Br

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
CA4 P22748 1/20 0.40
CA6 P23280 1/20 0.40
ACHE P22303 1/20 0.38
ALOX15 P16050 4/20 0.37
ALOX12 P18054 2/20 0.37
NQO2 P16083 1/20 0.36
APEX1 P27695 1/20 0.35
AKR1B1 P15121 1/20 0.34
LMNA P02545 2/20 0.32
HPGD P15428 2/20 0.32
HTT P42858 2/20 0.32
KDM4E B2RXH2 1/20 0.32
NSD2 O96028 1/20 0.32
ALDH1A1 P00352 1/20 0.32
POLB P06746 1/20 0.32
GAA P10253 1/20 0.32
MAPT P10636 1/20 0.32
MAPK1 P28482 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25581857 0.86 ACHE (0.43) CA1CA2CA4CA6ACHE
SCHEMBL27584888 0.84 ACHE (0.43) CA1CA2CA4CA6ACHE
SCHEMBL10888349 0.81 ALOX15 (0.34) CA1CA2CA4CA6ACHE
SCHEMBL1547096 0.80 APEX1 (0.44) CA1CA2CA4CA6NQO2
SCHEMBL27985290 0.79 ACHE (0.38) CA1CA2CA4CA6ACHE
SCHEMBL28498022 0.79 ACHE (0.43) CA1CA2CA4CA6ACHE
Ethane SCHEMBL10514068 0.76 PTPN1 (0.43) CA1CA2CA4CA6ALOX15
SCHEMBL144299 0.75 PTPN1 (0.46) CA1CA2CA4CA6ALOX15
SCHEMBL30479640 0.75 PTPN1 (0.46) CA1CA2CA4CA6ALOX15
SCHEMBL10434111 0.74 ACHE (0.43) CA1CA2CA4CA6ACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112368304-A Substituted cyclodextrin-metal complexes and their use 生物西德克斯公司 2021-02-12 CN disclosed
CN-101237838-A Combination therapy for the treatment of immunoinflammatory disorders COMBINATORX INC (US) 2008-08-06 CN disclosed
EP-1073470-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2001-02-07 EP disclosed
WO-2000048636-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2000-08-24 WO disclosed
EP-1021204-A2 BIOADHESIVE COMPOSITIONS AND METHODS FOR TOPICAL ADMINISTRATION OF ACTIVE AGENTS NOVEN PHARMACEUTICALS, INC. (US) 2000-07-26 EP disclosed
WO-1999015210-A2 BIOADHESIVE COMPOSITIONS AND METHODS FOR TOPICAL ADMINISTRATION OF ACTIVE AGENTS NOVEN PHARMACEUTICALS, INC. (US) 1999-04-01 WO disclosed
US-5120325-A Color-matched sterile adhesive bandages containing melanin-like pigment composition FLESHTONES PRODUCTS CO., INC. (US) 1992-06-09 US disclosed
US-4425248-A CORROSION RESISTANCE, PARTIAL AMIDE MOBIL OIL CORPORATION (US) 1984-01-10 US disclosed
US-4402839-A COOLANTS; CORROSION RESISTANCE MOBIL OIL CORPORATION (US) 1983-09-06 US disclosed
US-4289636-A AMIDES DERIVED FROM ALKYLAMINES AND TETRAHYDROPHTHALIC OR TETRAHYDROFURAN TETRACARBOXYLIC ACIDS MOBIL OIL CORPORATION (US) 1981-09-15 US disclosed
US-4259206-A CORROSION RESISTANCE MOBIL OIL CORPORATION (US) 1981-03-31 US disclosed