Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | EDNRA | P25101 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7756380 | 0.85 | KMT2A (0.47) | KMT2ALMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL7756374 | 0.85 | KMT2A (0.47) | KMT2ALMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL6659963 | 0.83 | OPRM1 (0.43) | ALDH1A1SMN1; SMN2OPRM1 | |
| SCHEMBL6659961 | 0.83 | OPRM1 (0.43) | ALDH1A1SMN1; SMN2OPRM1 | |
| SCHEMBL6653711 | 0.81 | OPRM1 (0.47) | PKMMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL6653714 | 0.81 | OPRM1 (0.47) | PKMMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL6656375 | 0.79 | OPRM1 (0.44) | MEN1KMT2ASMN1; SMN2TP53OPRM1 | |
| SCHEMBL7757867 | 0.79 | OPRM1 (0.44) | MEN1KMT2ASMN1; SMN2TP53OPRM1 | |
| SCHEMBL7756051 | 0.79 | OPRM1 (0.44) | MEN1KMT2ASMN1; SMN2TP53OPRM1 | |
| SCHEMBL6656153 | 0.77 | TSHR (0.43) | MEN1KMT2ALMNAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077940-A1 | 4-PHENYLPIPERIDINES FOR THE TREATMENT OF PRURITIC DERMATOSES | PFIZER INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999059971-A1 | NOVEL 4-PHENYLPIPERIDINES FOR THE TREATMENT OF PRURITIC DERMATOSES | PFIZER INC. (US) | 1999-11-25 | — | — | WO | disclosed |