Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.41 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7756374 | 1.00 | KMT2A (0.47) | KMT2ABRD4GAAMAP2K7MAP2K4 | |
| SCHEMBL7754596 | 0.85 | PKM (0.45) | KMT2AGAAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL6659963 | 0.81 | OPRM1 (0.43) | BRD4ALDH1A1POLBSMN1; SMN2OPRM1 | |
| SCHEMBL6659961 | 0.81 | OPRM1 (0.43) | BRD4ALDH1A1POLBSMN1; SMN2OPRM1 | |
| SCHEMBL7755259 | 0.80 | BRD4 (0.49) | KMT2ABRD4GAAALDH1A1HTT | |
| SCHEMBL6653714 | 0.79 | OPRM1 (0.47) | KMT2ABRD4PARP1ALDH1A1OPRM1 | |
| SCHEMBL6653711 | 0.79 | OPRM1 (0.47) | KMT2ABRD4PARP1ALDH1A1OPRM1 | |
| SCHEMBL6656153 | 0.77 | TSHR (0.43) | KMT2AGAAPARP1TSHRALDH1A1 | |
| SCHEMBL6661166 | 0.77 | TSHR (0.43) | KMT2AGAAPARP1TSHRALDH1A1 | |
| SCHEMBL7756051 | 0.76 | OPRM1 (0.44) | KMT2ABRD4SMN1; SMN2NAMPTOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077940-A1 | 4-PHENYLPIPERIDINES FOR THE TREATMENT OF PRURITIC DERMATOSES | PFIZER INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999059971-A1 | NOVEL 4-PHENYLPIPERIDINES FOR THE TREATMENT OF PRURITIC DERMATOSES | PFIZER INC. (US) | 1999-11-25 | — | — | WO | disclosed |