Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.66 |
| ▸ | MMP7 | P09237 | 1/20 | 0.52 |
| ▸ | ITGB3 | P05106 | 7/20 | 0.51 |
| ▸ | ITGAV | P06756 | 7/20 | 0.51 |
| ▸ | ITGA2B | P08514 | 7/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | MMP1 | P03956 | 2/20 | 0.48 |
| ▸ | MMP2 | P08253 | 2/20 | 0.48 |
| ▸ | MMP9 | P14780 | 2/20 | 0.48 |
| ▸ | MMP8 | P22894 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.47 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3924110 | 1.00 | BACE1 (0.66) | BACE1MMP7ITGB3ITGAVITGA2B | |
| SCHEMBL6774068 | 0.81 | BACE1 (0.67) | BACE1MMP2MMP9MAPT | |
| SCHEMBL3927017 | 0.80 | BACE1 (0.76) | BACE1 | |
| SCHEMBL10914560 | 0.79 | BACE1 (0.71) | BACE1ITGB3ITGA2BMMP2MMP9 | |
| SCHEMBL3926872 | 0.79 | BACE1 (0.71) | BACE1ITGB3ITGA2BMMP2MMP9 | |
| SCHEMBL3924475 | 0.78 | BACE1 (0.73) | BACE1MMP7MMP1MMP2MMP9 | |
| SCHEMBL6415370 | 0.78 | BACE1 (0.56) | BACE1NPSR1CA1CA2L3MBTL1 | |
| SCHEMBL6029029 | 0.78 | ITGB3 (0.54) | MMP7ITGB3ITGAVITGA2BNPSR1 | |
| SCHEMBL3936334 | 0.77 | BACE1 (0.68) | BACE1NPSR1MMP2MMP9L3MBTL1 | |
| SCHEMBL3923618 | 0.77 | BACE1 (0.68) | BACE1MMP7MMP1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1076557-A1 | CCR-3 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-02-21 | — | — | EP | claimed |
| WO-1999055324-A1 | CCR-3 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-11-04 | — | — | WO | claimed |
| EP-1076557-A1 | CCR-3 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-02-21 | — | — | EP | disclosed |
| WO-1999055324-A1 | CCR-3 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-11-04 | — | — | WO | disclosed |