Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.47 |
| ▸ | HTR2A | P28223 | 7/20 | 0.47 |
| ▸ | DRD3 | P35462 | 7/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.47 |
| ▸ | DRD4 | P21917 | 6/20 | 0.47 |
| ▸ | DRD5 | P21918 | 6/20 | 0.47 |
| ▸ | HRH2 | P25021 | 6/20 | 0.47 |
| ▸ | HTR7 | P34969 | 6/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.47 |
| ▸ | HTR6 | P50406 | 6/20 | 0.47 |
| ▸ | HRH1 | P35367 | 5/20 | 0.47 |
| ▸ | HTR1A | P08908 | 5/20 | 0.47 |
| ▸ | DRD2 | P14416 | 5/20 | 0.47 |
| ▸ | HTR2C | P28335 | 5/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.47 |
| ▸ | HTR2B | P41595 | 4/20 | 0.47 |
| ▸ | DRD1 | P21728 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7754343 | 0.90 | CYP3A4 (0.53) | SLC6A3HTR2ADRD3OPRK1OPRD1 | |
| SCHEMBL7754861 | 0.89 | DRD3 (0.48) | SLC6A3HTR2ADRD3OPRK1OPRD1 | |
| Hydrochloric Acid SCHEMBL7542285 | 0.88 | MEN1 (0.54) | SLC6A3HTR2ADRD3OPRK1OPRD1 | |
| SCHEMBL9416417 | 0.88 | SLC6A3 (0.42) | SLC6A3HTR2ADRD3OPRK1OPRD1 | |
| SCHEMBL7751395 | 0.85 | CYP3A4 (0.49) | SLC6A3HTR2ADRD3OPRK1OPRD1 | |
| SCHEMBL8616378 | 0.85 | CYP3A4 (0.51) | SLC6A3HTR2ADRD3OPRK1OPRD1 | |
| SCHEMBL4760958 | 0.85 | CYP3A4 (0.51) | SLC6A3HTR2ADRD3OPRK1OPRD1 | |
| SCHEMBL8615736 | 0.85 | CYP3A4 (0.51) | SLC6A3HTR2ADRD3OPRK1OPRD1 | |
| SCHEMBL7754348 | 0.85 | SLC6A3 (0.52) | SLC6A3HTR2ADRD3OPRK1OPRD1 | |
| SCHEMBL7754359 | 0.85 | CYP3A4 (0.48) | SLC6A3HTR2ADRD3OPRK1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0706796-B1 | DOPAMINE RE-UPTAKE INHIBITORS FOR THE TREATMENT OF PARKINSON'S SYNDROME | POLA CHEM IND INC (JP) | 2001-02-28 | — | — | EP | claimed |
| US-5747493-A | N-/DIPHENYLALKYL/-PIPERAZINYL-2-HYDROXYPROPYLAMINES | POLA CHEMICAL INDUSTRIES, INC. (JP) | 1998-05-05 | — | — | US | claimed |
| EP-0706796-A1 | DOPAMINE REINCORPORATION INHIBITOR | POLA CHEMICAL INDUSTRIES, INC. (JP) | 1996-04-17 | — | — | EP | claimed |
| EP-0549796-B1 | DIPHENYLPIPERAZINE DERIVATIVE AND DRUG FOR CIRCULATORY ORGAN CONTAINING THE SAME | POLA CHEM IND INC (JP) | 1998-04-29 | — | — | EP | disclosed |
| US-5391552-A | Has strong antagonism against calcium with less side effects | POLA CHEMICAL INDUSTRIES, INC. (JP) | 1995-02-21 | — | — | US | disclosed |
| EP-0549796-A1 | DIPHENYLPIPERAZINE DERIVATIVE AND DRUG FOR CIRCULATORY ORGAN CONTAINING THE SAME | POLA CHEMICAL INDUSTRIES INC (JP) | 1993-07-07 | — | — | EP | disclosed |