SCHEMBL7755825

SCHEMBL7755825

CCCCC[Si@H]1CC[C@H](c2ccc(-c3ccc(OC(F)F)c(F)c3)cc2)CC1

nearest known ligand 0.34

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 4/20 0.34
TLR7 Q9NYK1 1/20 0.33
FPR2 P25090 1/20 0.33
PDE4D Q08499 2/20 0.32
GRM2 Q14416 2/20 0.31
KCNH2 Q12809 2/20 0.31
GRIN2B Q13224 2/20 0.31
MAPT P10636 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30
RARB P10826 3/20 0.30
RARA P10276 2/20 0.30
RARG P13631 1/20 0.30
NAAA Q02083 1/20 0.30
SPHK1 Q9NYA1 1/20 0.30
ESR2 Q92731 1/20 0.30
PDE4A P27815 1/20 0.30
PDE4B Q07343 1/20 0.30
PDE4C Q08493 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7755821 1.00 MGLL (0.34) MGLLTLR7FPR2PDE4DGRM2
SCHEMBL7753064 0.92 FPR2 (0.34) MGLLFPR2PDE4DGRM2KCNH2
SCHEMBL7753068 0.92 FPR2 (0.34) MGLLFPR2PDE4DGRM2KCNH2
SCHEMBL8014690 0.92 MGLL (0.31) MGLLFPR2ESR2PDE4B
SCHEMBL8014693 0.92 MGLL (0.31) MGLLFPR2ESR2PDE4B
SCHEMBL9008584 0.92 MGLL (0.31) MGLLFPR2ESR2PDE4B
SCHEMBL8014697 0.92 MGLL (0.31) MGLLFPR2ESR2PDE4B
SCHEMBL7757235 0.88 GRM2 (0.33) GRM2NAAA
SCHEMBL7757239 0.88 GRM2 (0.33) GRM2NAAA
SCHEMBL8398127 0.88 SPHK1 (0.30) TLR7SPHK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0718387-B1 A liquid crystal composition and a liquid crystal display element which contains it SHINETSU CHEMICAL CO (JP) 2001-03-14 EP disclosed
US-5951913-A Liquid crystal compositions comprising silacyclohexane compounds SHIN-ETSU CHEMICAL CO., LTD. (JP) 1999-09-14 US disclosed
EP-0650969-B1 A Silacyclohexane compound, a method of preparing it and a liquid crystal composition containing it SHINETSU CHEMICAL CO (JP) 1999-05-26 EP disclosed
US-5762826-A Liquid crystal composition and a liquid crystal display element which contains it SHIN-ETSU CHEMICAL CO., LTD. (JP) 1998-06-09 US disclosed
US-5755995-A DISAZO DYES, TRISAZO DYES AND ANTHRAQUINONE DYES WITH LIQUID CRYSTAL POLYMERS SHIN-ETSU CHEMICAL CO., LTD. (JP) 1998-05-26 US disclosed
US-5730901-A Silacyclohexane compounds, preparation thereof liquid crystal compositions comprising the same, and liquid crystal devices comprising the composition SHIN-ETSU CHEMICAL CO., LTD. (JP) 1998-03-24 US disclosed
EP-0799878-A1 Liquid crystal compositions and liquid crystal display elements containing same Shin-Etsu Chemical Co., Ltd. (JP) 1997-10-08 EP disclosed
US-5659059-A Silacyclohexane compound, a method of preparing it and a liquid crystal composition containing it SHIN-ETSU CHEMICAL CO., LTD. (JP) 1997-08-19 US disclosed
EP-0718387-A1 A liquid crystal composition and a liquid crystal display element which contains it SHIN-ETSU CHEMICAL CO., LTD. (JP) 1996-06-26 EP disclosed
EP-0650969-A1 A Silacyclohexane compound, a method of preparing it and a liquid crystal composition containing it Shin-Etsu Chemical Co., Ltd. (JP) 1995-05-03 EP disclosed