Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.71 |
| ▸ | MEN1 | O00255 | 4/20 | 0.71 |
| ▸ | NPC1 | O15118 | 4/20 | 0.71 |
| ▸ | RAB9A | P51151 | 4/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.71 |
| ▸ | MAPT | P10636 | 3/20 | 0.71 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.71 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.71 |
| ▸ | HTT | P42858 | 1/20 | 0.71 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.63 |
| ▸ | CDK2 | P24941 | 6/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MELK | Q14680 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7753417 | 0.80 | CCNA2 (0.68) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6611369 | 0.78 | CDK5 (0.72) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6755564 | 0.73 | CDK5 (0.56) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6607604 | 0.73 | CDK5 (0.64) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL6617607 | 0.72 | CDK5 (0.62) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4399817 | 0.69 | NPC1 (0.65) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9144815 | 0.67 | F2 (0.70) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27459154 | 0.66 | ALDH1A1 (0.47) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4399377 | 0.65 | CCNA2 (0.77) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL544522 | 0.65 | ALDH1A1 (0.60) | KMT2AMEN1SMN1; SMN2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001056567-A1 | 2,4-DIAMINOTHIAZOLE DERIVATIVES AND THEIR USE AS GLYCOGEN SYNTHASE KINASE-3 (GSK-3) INHIBITORS | NOVO NORDISK A/S (DK) | 2001-08-09 | — | — | WO | disclosed |