Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL429369 | 0.86 | ALDH1A1 (0.47) | CYP1A2CYP2D6MAPTPOLBL3MBTL1 | |
| SCHEMBL8393177 | 0.82 | TLR9 (0.51) | MAPTKMT2AHTTALDH1A1MEN1 | |
| SCHEMBL1051793 | 0.82 | CYP1A2 (0.61) | CYP1A2CYP2D6HSD17B10MAPTKMT2A | |
| SCHEMBL1051792 | 0.82 | CYP1A2 (0.61) | CYP1A2CYP2D6HSD17B10MAPTKMT2A | |
| SCHEMBL8140778 | 0.81 | CYP1A2 (0.60) | CYP1A2CYP2D6HSD17B10MAPTKMT2A | |
| SCHEMBL8140783 | 0.81 | CYP1A2 (0.60) | CYP1A2CYP2D6HSD17B10MAPTKMT2A | |
| SCHEMBL9775572 | 0.81 | ALDH1A1 (0.48) | CYP1A2CYP2D6MAPTKMT2APOLB | |
| SCHEMBL9775574 | 0.81 | ALDH1A1 (0.48) | CYP1A2CYP2D6MAPTKMT2APOLB | |
| SCHEMBL6983075 | 0.80 | CYP1A2 (0.56) | CYP1A2CYP2D6HSD17B10MAPTKMT2A | |
| SCHEMBL6983081 | 0.80 | CYP1A2 (0.56) | CYP1A2CYP2D6HSD17B10MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0777650-B1 | BIPHENYLAMIDE DERIVATIVES AS 5HT 1D ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2001-03-07 | — | — | EP | disclosed |
| US-5889022-A | Indole, indoline and quinoline derivatives with 5HT1D (anti-depressive) activity | SMITHKLINE BEECHAM, P.L.C. (GB) | 1999-03-30 | — | — | US | disclosed |
| US-5817833-A | Biphenylamide compounds as 5HT1D Antagonists | SMITHKLINE BEECHAM P.L.C. (GB) | 1998-10-06 | — | — | US | disclosed |
| EP-0736023-B1 | INDOLE, INDOLINE AND QUINOLINE DERIVATIVES WITH 5HT 1D (ANTI-DEPRESSIVE) ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1998-07-08 | — | — | EP | disclosed |
| EP-0777650-A1 | BIPHENYLAMIDE DERIVATIVES AS 5HT 1D? ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-06-11 | — | — | EP | disclosed |
| EP-0736023-A1 | INDOLE, INDOLINE AND QUINOLINE DERIVATIVES WITH 5HT 1D? (ANTI-DEPRESSIVE) ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1996-10-09 | — | — | EP | disclosed |
| WO-1996006079-A1 | BIPHENYLAMIDE DERIVATIVES AS 5HT1D ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-02-29 | — | — | WO | disclosed |
| WO-1995017398-A1 | INDOLE, INDOLINE AND QUINOLINE DERIVATIVES WITH 5HT1D (ANTI-DEPRESSIVE) ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1995-06-29 | — | — | WO | disclosed |