Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.58 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.58 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.58 |
| ▸ | CTSS | P25774 | 1/20 | 0.56 |
| ▸ | CTSK | P43235 | 1/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL705394 | 0.95 | CTSS (0.56) | OPRM1OPRD1OPRK1SLC18A2CTSS | |
| SCHEMBL60979 | 0.93 | CTSS (0.54) | OPRM1OPRD1OPRK1SLC18A2CTSS | |
| SCHEMBL1609623 | 0.91 | MAOA (0.58) | SLC18A2CTSSCTSKMAOAMAOB | |
| Ammonia Solution, Strong SCHEMBL20702116 | 0.85 | SLC18A3 (0.56) | OPRM1OPRD1OPRK1SLC18A2 | |
| SCHEMBL6399379 | 0.85 | CTSS (0.48) | OPRM1OPRD1OPRK1SLC18A2CTSS | |
| SCHEMBL16191113 | 0.83 | SLC18A2 (0.51) | OPRM1OPRD1OPRK1SLC18A2CTSS | |
| SCHEMBL6399518 | 0.83 | CTSS (0.47) | OPRM1OPRD1OPRK1SLC18A2CTSS | |
| SCHEMBL16191193 | 0.83 | SLC18A2 (0.51) | OPRM1OPRD1OPRK1SLC18A2CTSS | |
| SCHEMBL7103234 | 0.83 | SLC18A3 (0.62) | OPRM1OPRD1OPRK1 | |
| SCHEMBL3172080 | 0.82 | MAOA (0.47) | SLC18A2CTSSCTSKMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108137508-A | 5-HT2CReceptor agonists and compositions and methods of use | 艾尼纳制药公司 | 2018-06-08 | — | — | CN | disclosed |
| EP-1090908-A2 | Cyclobutane derivatives as inhibitors of protein farnesyltransferase | ABBOTT LABORATORIES (US) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000058346-A1 | N-SULFONYL-DIPEPTIDE DERIVATIVES, PRODUCTION AND USE THEREOF IN THERAPY | SANOFI-SYNTHELABO (FR) | 2000-10-05 | — | — | WO | disclosed |
| EP-0677039-B1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LAB (US) | 1999-03-10 | — | — | EP | disclosed |
| US-5831115-A | CYCLOBUTANECARBOXAMIDES | ABBOTT LABORATORIES (US) | 1998-11-03 | — | — | US | disclosed |
| US-5783593-A | FUNGICIDE; ANTICHOLESTEROL AGENT | ABBOTT LABORATORIES (US) | 1998-07-21 | — | — | US | disclosed |
| EP-0821665-A1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHASE AND PROTEIN FARNESYLTRANSFERASE | Abbott Laboratories (US) | 1998-02-04 | — | — | EP | disclosed |
| WO-1996034851-A1 | BENZENE, PYRIDINE, NAPHTALENE OR BENZOPHENONE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1996-11-07 | — | — | WO | disclosed |
| WO-1996034850-A1 | CYCLOBUTANE DERIVATIVES AND THEIR USE AS INHIBITORS OF PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1996-11-07 | — | — | WO | disclosed |
| WO-1996033159-A1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1996-10-24 | — | — | WO | disclosed |
| EP-0677039-A1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | Abbott Laboratories (US) | 1995-10-18 | — | — | EP | disclosed |
| WO-1995012572-A1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1995-05-11 | — | — | WO | disclosed |