Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 8/20 | 0.52 |
| ▸ | PTGES | O14684 | 2/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.46 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.44 |
| ▸ | EPOR | P19235 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22778379 | 0.78 | CA1 (0.51) | CA1CA2 | |
| SCHEMBL28420914 | 0.78 | CA1 (0.50) | CA1CA2 | |
| SCHEMBL28428910 | 0.77 | CA1 (0.52) | CA1CA2 | |
| SCHEMBL28426731 | 0.77 | CA1 (0.52) | CA1CA2 | |
| SCHEMBL17879694 | 0.76 | CA1 (0.55) | BCHECA1CA2 | |
| SCHEMBL7757382 | 0.75 | L3MBTL1 (0.56) | BCHENR4A2MAOBFFAR1ALOX5 | |
| SCHEMBL28421181 | 0.75 | CA1 (0.50) | CA1CA2 | |
| SCHEMBL10502279 | 0.75 | PPARG (0.56) | MAOBCA1CA2 | |
| SCHEMBL1137350 | 0.75 | ALDH1A1 (0.67) | BCHENR4A2LTB4RLTB4R2MAOB | |
| SCHEMBL7571319 | 0.74 | ALDH1A1 (0.59) | CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0767800-B1 | HISTIDINE AND HOMOHISTIDINE DERIVATIVES AS INHIBITORS OF PROTEIN FARNESYLTRANSFERASE | WARNER LAMBERT CO (US) | 2001-03-28 | — | — | EP | disclosed |
| US-5571792-A | Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase | WARNER-LAMBERT COMPANY (US) | 1996-11-05 | — | — | US | disclosed |