Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | LTA4H | P09960 | 3/20 | 0.48 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7758247 | 0.94 | SMN1; SMN2 (0.50) | SMN1; SMN2HTTLMNALTA4HASAH1 | |
| SCHEMBL12292971 | 0.87 | SMN1; SMN2 (0.59) | SMN1; SMN2HTTLMNAASAH1EPHX2 | |
| SCHEMBL16620624 | 0.81 | TAAR1 (0.57) | SMN1; SMN2HTTLMNAEPHX2KDM4E | |
| SCHEMBL16620502 | 0.80 | TSHR (0.54) | SMN1; SMN2HTTLMNANPC1RAB9A | |
| SCHEMBL10585453 | 0.79 | SMN1; SMN2 (0.61) | SMN1; SMN2HTTLMNAASAH1KDM4E | |
| SCHEMBL7754370 | 0.78 | GID4 (0.61) | MEN1KMT2A | |
| SCHEMBL8760991 | 0.78 | SMN1; SMN2 (0.60) | SMN1; SMN2HTTLMNALTA4HASAH1 | |
| SCHEMBL3508948 | 0.78 | SMN1; SMN2 (0.62) | SMN1; SMN2HTTLMNAASAH1EPHX2 | |
| SCHEMBL13033025 | 0.78 | SMN1; SMN2 (0.60) | SMN1; SMN2HTTLMNAASAH1KDM4E | |
| SCHEMBL29025356 | 0.78 | EPHX2 (0.57) | SMN1; SMN2HTTLMNAEPHX2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0767800-B1 | HISTIDINE AND HOMOHISTIDINE DERIVATIVES AS INHIBITORS OF PROTEIN FARNESYLTRANSFERASE | WARNER LAMBERT CO (US) | 2001-03-28 | — | — | EP | disclosed |