Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.44 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.43 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.43 |
| ▸ | PSMD12 | O00232 | 1/20 | 0.43 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.43 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.43 |
| ▸ | PSMD3 | O43242 | 1/20 | 0.43 |
| ▸ | PSMC3 | P17980 | 1/20 | 0.43 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7758240 | 0.94 | SMN1; SMN2 (0.53) | SMN1; SMN2HTTEPHX2LMNAMMP3 | |
| SCHEMBL12292971 | 0.84 | SMN1; SMN2 (0.59) | SMN1; SMN2HTTEPHX2LMNAASAH1 | |
| SCHEMBL16620624 | 0.84 | TAAR1 (0.57) | SMN1; SMN2HTTEPHX2LMNAL3MBTL1 | |
| SCHEMBL29025356 | 0.81 | EPHX2 (0.57) | SMN1; SMN2HTTEPHX2LMNAMMP3 | |
| SCHEMBL8099440 | 0.81 | HDAC3 (0.57) | HTTEPHX2LMNAMMP3MMP9 | |
| SCHEMBL880293 | 0.81 | SMN1; SMN2 (0.55) | SMN1; SMN2HTTLMNALTA4HASAH1 | |
| SCHEMBL25375626 | 0.80 | LMNA (0.55) | SMN1; SMN2HTTEPHX2LMNATRPV1 | |
| SCHEMBL7694478 | 0.80 | L3MBTL1 (0.58) | SMN1; SMN2HTTEPHX2LMNAMMP3 | |
| SCHEMBL21069431 | 0.78 | EPHX2 (0.61) | SMN1; SMN2HTTEPHX2LMNAMMP3 | |
| SCHEMBL21071040 | 0.78 | EPHX2 (0.61) | SMN1; SMN2HTTEPHX2LMNAMMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0767800-B1 | HISTIDINE AND HOMOHISTIDINE DERIVATIVES AS INHIBITORS OF PROTEIN FARNESYLTRANSFERASE | WARNER LAMBERT CO (US) | 2001-03-28 | — | — | EP | disclosed |