Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 17/20 | 0.60 |
| ▸ | ADRA2B | P18089 | 16/20 | 0.60 |
| ▸ | ADRA2C | P18825 | 16/20 | 0.60 |
| ▸ | ADRA1D | P25100 | 13/20 | 0.60 |
| ▸ | ADRA1B | P35368 | 12/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 12/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7754567 | 0.91 | ADRA2A (0.60) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL7759463 | 0.82 | ADRA2A (0.68) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL9358511 | 0.81 | ADRA2A (0.53) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL7758549 | 0.80 | ADRA2A (0.68) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL7759458 | 0.76 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL9359095 | 0.75 | ADRA2A (0.59) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL7787375 | 0.73 | ADRA2A (0.55) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL7754560 | 0.71 | ADRA2A (0.67) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL7757805 | 0.71 | ADRA2A (0.67) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL7032965 | 0.68 | ADRA2A (0.59) | ADRA2AADRA2BADRA2CADRA1DADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0620732-B1 | METHODS FOR USING (2-IMIDAZOLIN-2-YLAMINO) QUINOXALINE DERIVATIVES | ALLERGAN INC (US) | 2001-04-04 | — | — | EP | disclosed |
| US-5418234-A | Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives | ALLERGAN, INC. (US) | 1995-05-23 | — | — | US | disclosed |
| EP-0549594-B1 | (2-IMIDAZOLIN-2-YLAMINO) QUINOXALINE DERIVATIVES AND METHODS FOR USING SAME | ALLERGAN INC (US) | 1995-02-01 | — | — | EP | disclosed |
| US-5373010-A | Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives | ALLERGAN, INC. (US) | 1994-12-13 | — | — | US | disclosed |
| US-5326763-A | Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives | ALLERGAN, INC. (US) | 1994-07-05 | — | — | US | disclosed |
| US-5231096-A | Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives | ALLERGAN, INC. (US) | 1993-07-27 | — | — | US | disclosed |
| EP-0549594-A1 | (2-IMIDAZOLIN-2-YLAMINO) QUINOXALINE DERIVATIVES AND METHODS FOR USING SAME. | ALLERGAN INC (US) | 1993-07-07 | — | — | EP | disclosed |
| EP-0549594-A4 | (2-IMIDAZOLIN-2-YLAMINO) QUINOXALINE DERIVATIVES AND METHODS FOR USING SAME. | ALLERGAN INC (US) | 1993-04-16 | — | — | EP | disclosed |
| US-5198442-A | (2-imidazolin-2-ylamino) quinoxaline derivatives and methods for using same | ALLERGAN, INC. (US) | 1993-03-30 | — | — | US | disclosed |
| WO-1992002515-A1 | (2-IMIDAZOLIN-2-YLAMINO) QUINOXALINE DERIVATIVES AND METHODS FOR USING SAME | ALLERGAN, INC. (US) | 1992-02-20 | — | — | WO | disclosed |