Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 17/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 17/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 17/20 | 1.00 |
| ▸ | ADRA1D | P25100 | 13/20 | 1.00 |
| ▸ | ADRA1B | P35368 | 12/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 11/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9420416 | 0.87 | ADRA2A (0.77) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| Hydrochloric Acid SCHEMBL9463952 | 0.86 | ADRA2A (0.74) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL29426313 | 0.82 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL7759463 | 0.81 | ADRA2A (0.68) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL7758549 | 0.81 | ADRA2A (0.68) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL7757805 | 0.80 | ADRA2A (0.67) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL7754560 | 0.80 | ADRA2A (0.67) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL9259370 | 0.76 | ADRA2A (0.61) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL7754567 | 0.76 | ADRA2A (0.60) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL7758519 | 0.76 | ADRA2A (0.60) | ADRA2AADRA2BADRA2CADRA1DADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-3145490-A | — | — | None | — | — | JP | disclosed |
| EP-0620732-B1 | METHODS FOR USING (2-IMIDAZOLIN-2-YLAMINO) QUINOXALINE DERIVATIVES | ALLERGAN INC (US) | 2001-04-04 | — | — | EP | disclosed |
| US-5418234-A | Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives | ALLERGAN, INC. (US) | 1995-05-23 | — | — | US | disclosed |
| US-5373010-A | Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives | ALLERGAN, INC. (US) | 1994-12-13 | — | — | US | disclosed |
| EP-0620732-A1 | METHODS FOR USING (2-IMIDAZOLIN-2-YLAMINO) QUINOXALINE DERIVATIVES | ALLERGAN, INC. (US) | 1994-10-26 | — | — | EP | disclosed |
| US-5326763-A | Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives | ALLERGAN, INC. (US) | 1994-07-05 | — | — | US | disclosed |
| EP-0422878-B1 | (2-Imidazolin-2-ylamino) tetrahydroquinoxalines and methods for using same | ALLERGAN INC (US) | 1994-04-27 | — | — | EP | disclosed |
| US-5300504-A | Increasing renal fluid flow | ALLERGAN, INC. (US) | 1994-04-05 | — | — | US | disclosed |
| US-5231096-A | Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives | ALLERGAN, INC. (US) | 1993-07-27 | — | — | US | disclosed |
| WO-1993013771-A1 | METHODS FOR USING (2-IMIDAZOLIN-2-YLAMINO) QUINOXALINE DERIVATIVES | ALLERGAN, INC. (US) | 1993-07-22 | — | — | WO | disclosed |
| US-5204347-A | Reduction in intraocular pressure; increase renal flow; alteration in the rate of fluid transport in the gastrointestinal tract | ALLERGAN, INC. (US) | 1993-04-20 | — | — | US | disclosed |
| WO-1992013855-A1 | (2-IMIDAZOLIN-2-YLAMINO) TETRAHYDROQUINOLAXINES AND METHODS FOR USING SAME | ALLERGAN, INC. (US) | 1992-08-20 | — | — | WO | disclosed |
| US-5077292-A | Gastrointestinal disordes; kidney and vision defects | ALLERGAN, INC. (US) | 1991-12-31 | — | — | US | disclosed |
| JP-H03145490-A | (2IMIDAZOLIN2-YLAMINO) TETRAHYDROQUINOXALINE | ALLERGAN INC | 1991-06-20 | — | — | JP | disclosed |
| EP-0422878-A1 | (2-Imidazolin-2-ylamino) tetrahydroquinoxalines and methods for using same | ALLERGAN, INC. (US) | 1991-04-17 | — | — | EP | disclosed |