Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QPCT | Q16769 | 4/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.40 |
| ▸ | NAMPT | P43490 | 6/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.39 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.37 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7758570 | 1.00 | QPCT (0.40) | QPCTP2RX7NAMPTEPHX2TMPRSS4 | |
| SCHEMBL4260986 | 0.90 | QPCT (0.44) | QPCTNAMPTTBXA2RTBXAS1KCNJ11 | |
| SCHEMBL4260989 | 0.90 | QPCT (0.44) | QPCTNAMPTTBXA2RTBXAS1KCNJ11 | |
| SCHEMBL7758049 | 0.90 | QPCT (0.44) | QPCTNAMPTTBXA2RTBXAS1KCNJ11 | |
| SCHEMBL8134099 | 0.77 | QPCT (0.47) | QPCTNAMPTTMPRSS4KCNJ11 | |
| SCHEMBL8134103 | 0.77 | QPCT (0.47) | QPCTNAMPTTMPRSS4KCNJ11 | |
| SCHEMBL7758583 | 0.77 | KIF11 (0.33) | P2RX7EPHX2TMPRSS4 | |
| SCHEMBL8138720 | 0.75 | EPHX2 (0.43) | P2RX7EPHX2TMPRSS4KCNJ11 | |
| SCHEMBL7753776 | 0.74 | TBXA2R (0.42) | QPCTNAMPTTBXA2RTBXAS1KCNJ11 | |
| SCHEMBL7753772 | 0.74 | TBXA2R (0.42) | QPCTNAMPTTBXA2RTBXAS1KCNJ11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6147098-A | USEFUL IN THE TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM, CARDIOVASCULAR SYSTEM, PULMONARY SYSTEM, GASTROINTESTINAL SYSTEM AND ENDOCRINOLOGIC SYSTEM | NOVO NORDISK A/S (DK) | 2000-11-14 | — | — | US | claimed |
| EP-1077933-A1 | SUBSTITUTED GUANIDINES AND DIAMINONITROETHENES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 2001-02-28 | — | — | EP | disclosed |
| US-6147098-A | USEFUL IN THE TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM, CARDIOVASCULAR SYSTEM, PULMONARY SYSTEM, GASTROINTESTINAL SYSTEM AND ENDOCRINOLOGIC SYSTEM | NOVO NORDISK A/S (DK) | 2000-11-14 | — | — | US | disclosed |
| WO-1999058497-A1 | SUBSTITUTED GUANIDINES AND DIAMINONITROETHENES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1999-11-18 | — | — | WO | disclosed |