Histidine

SCHEMBL7758637

CC(C)C[C@H](N)C(=O)O[C@H](C)[C@H](N)C(=O)O.CC[C@H](C)[C@H](N)C(=O)O.CSCC[C@H](N)C(=O)O.NC(=O)C[C@H](N)C(=O)O.NCC(=O)O.NCC(=O)O.NCC(=O)O.NCCCC[C@H](N)C(=O)O.N[C@@H](CS)C(=O)O.N[C@@H](CS)C(=O)O.N[C@@H](Cc1c[nH]cn1)C(=O)O.O=C(O)[C@@H]1CCCN1.O=C(O)[C@@H]1CCCN1.O=C(O)[C@@H]1CCCN1

nearest known ligand 0.32

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

PPARD PTGS1 PTGS2 dacA dacB dacC ftsI mrcA mrcB mrdA

The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 3)

	gene	UniProt	supporting neighbours	confidence
▸	CALCR	P30988	3/20	0.32

▸	CRHR1	P34998	1/20	0.30

▸	CRHR2	Q13324	1/20	0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Histidine SCHEMBL7756448	0.95	—	—
Histidine SCHEMBL7758642	0.94	CALCR (0.34)	CALCRCRHR1CRHR2
Histidine SCHEMBL6556851	0.91	—	—
Histidine SCHEMBL7756453	0.89	CALCR (0.32)	CALCRCRHR1CRHR2
Histidine SCHEMBL6554544	0.87	MEN1 (0.30)	—
Histidine SCHEMBL6556855	0.86	CALCR (0.32)	CALCRCRHR1CRHR2
Phenylalanine SCHEMBL28835549	0.84	CALCR (0.40)	CALCRCRHR1CRHR2
Histidine SCHEMBL5578065	0.82	—	—
Histidine SCHEMBL7759763	0.81	GSR (0.32)	—
Cystine SCHEMBL9697229	0.81	CALCR (0.37)	CALCRCRHR1CRHR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-1082340-A1	PEPTIDE VACCINE FOR CANINE ALLERGY	IDEXX LABORATORIES, INC. (US)	2001-03-14	—	—	EP	claimed
WO-2000058349-A1	PEPTIDE VACCINE FOR CANINE ALLERGY	IDEXX LABORATORIES, INC. (US)	2000-10-05	—	—	WO	claimed