Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidine SCHEMBL7756453 | 0.92 | CALCR (0.32) | — | |
| Histidine SCHEMBL7758642 | 0.90 | CALCR (0.34) | — | |
| Histidine SCHEMBL28519332 | 0.90 | MEN1 (0.31) | MEN1KMT2A | |
| Histidine SCHEMBL6556855 | 0.89 | CALCR (0.32) | — | |
| Histidine SCHEMBL7756448 | 0.89 | — | — | |
| Histidine SCHEMBL7758637 | 0.87 | CALCR (0.32) | — | |
| Histidine SCHEMBL5064964 | 0.85 | MEN1 (0.36) | MEN1KMT2A | |
| Histidine SCHEMBL10609584 | 0.85 | — | — | |
| Histidine SCHEMBL10609589 | 0.85 | — | — | |
| Histidine SCHEMBL6556851 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0957111-B1 | Specific binding proteins for treating canine allergy | IDEXX LAB INC (US) | 2004-12-29 | — | — | EP | claimed |
| EP-1082340-A1 | PEPTIDE VACCINE FOR CANINE ALLERGY | IDEXX LABORATORIES, INC. (US) | 2001-03-14 | — | — | EP | claimed |
| WO-2000058349-A1 | PEPTIDE VACCINE FOR CANINE ALLERGY | IDEXX LABORATORIES, INC. (US) | 2000-10-05 | — | — | WO | claimed |
| EP-0955311-A2 | Peptide vaccine for canine allergy | IDEXX LABORATORIES, INC. (US) | 1999-11-10 | — | — | EP | claimed |