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Histidine

Histidine

SCHEMBL6556855

CC(C)C[C@H](N)C(=O)O.CC(C)[C@H](N)C(=O)O.CC[C@H](C)[C@H](N)C(=O)O.CSCC[C@H](N)C(=O)O.C[C@@H](O)[C@H](N)C(=O)O.NC(=O)C[C@H](N)C(=O)O.NCC(=O)O.NCC(=O)O.NCC(=O)O.N[C@@H](CO)C(=O)O.N[C@@H](CS)C(=O)O.N[C@@H](CS)C(=O)O.N[C@@H](Cc1c[nH]cn1)C(=O)O.O=C(O)[C@@H]1CCCN1.O=C(O)[C@@H]1CCCN1.O=C(O)[C@@H]1CCCN1

nearest known ligand 0.32

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

SLC5A2

The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ CALCR P30988 3/20 0.32
▸ CRHR1 P34998 1/20 0.31
▸ CRHR2 Q13324 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Histidine SCHEMBL7756453 0.98 CALCR (0.32) CALCRCRHR1CRHR2
Histidine SCHEMBL7758642 0.93 CALCR (0.34) CALCRCRHR1CRHR2
Histidine SCHEMBL7756448 0.91 — —
Histidine SCHEMBL6554544 0.89 MEN1 (0.30) —
Phenylalanine SCHEMBL28835549 0.87 CALCR (0.40) CALCRCRHR1CRHR2
Tyrosine SCHEMBL27498286 0.87 CALCR (0.40) CALCRCRHR1CRHR2
Histidine SCHEMBL7758637 0.86 CALCR (0.32) CALCRCRHR1CRHR2
Histidine SCHEMBL6556851 0.86 — —
Histidine SCHEMBL28633479 0.86 — —
Histidine SCHEMBL28528367 0.86 — —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0957111-B1 Specific binding proteins for treating canine allergy IDEXX LAB INC (US) 2004-12-29 — — EP disclosed
US-6734287-B1 SPECIFICALLY BIND TO AN ISOLATED AND PURIFIED PEPTIDE COMPRISING A LEUCINE POSITIONED TWO PEPTIDE BONDS AWAY FROM A TYROSINE-ARGININE PAIR; PROVIDE IMMUNITY TO DOG'S IMMUNOGLOBULIN E MOLECULES IDEXX LABORATORIES, INC. 2004-05-11 — — US disclosed
EP-0957111-A2 Specific binding proteins for treating canine allergy IDEXX LABORATORIES, INC. (US) 1999-11-17 — — EP disclosed
EP-0955311-A2 Peptide vaccine for canine allergy IDEXX LABORATORIES, INC. (US) 1999-11-10 — — EP disclosed