Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 9/20 | 0.62 |
| ▸ | APP | P05067 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 9/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.49 |
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | HTT | P42858 | 5/20 | 0.49 |
| ▸ | THRB | P10828 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | VDR | P11473 | 4/20 | 0.49 |
| ▸ | RECQL | P46063 | 3/20 | 0.49 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | ALPG | P10696 | 2/20 | 0.48 |
| ▸ | GFER | P55789 | 2/20 | 0.48 |
| ▸ | MMP14 | P50281 | 1/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL7758714 | 1.00 | MAPT (0.62) | MAPTAPPMEN1KMT2ALMNA | |
| SCHEMBL13245094 | 0.99 | MAPT (0.62) | MAPTAPPMEN1KMT2ALMNA | |
| SCHEMBL10035982 | 0.99 | MAPT (0.62) | MAPTAPPMEN1KMT2ALMNA | |
| SCHEMBL1405400 | 0.91 | APP (0.53) | MAPTAPPMEN1KMT2ALMNA | |
| SCHEMBL1405401 | 0.91 | APP (0.53) | MAPTAPPMEN1KMT2ALMNA | |
| SCHEMBL25664248 | 0.89 | MAPT (0.72) | MAPTAPPMEN1KMT2ALMNA | |
| Iodide SCHEMBL28090457 | 0.88 | MAPT (0.61) | MAPTAPPMEN1KMT2ALMNA | |
| SCHEMBL6128356 | 0.86 | MAPT (0.60) | MAPTAPPMEN1KMT2ALMNA | |
| Perchlorate SCHEMBL1532815 | 0.86 | KMT2A (0.54) | MAPTAPPMEN1KMT2ALMNA | |
| Perchlorate SCHEMBL29959735 | 0.86 | KMT2A (0.54) | MAPTAPPMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5891733-A | COMPRISING A BUFFER AGENT, AN OSMOTIC PRESSURE COMPENSATING AGENT,A FIRST DYE WHICH IS A CONDENSED BENZENE DERIVATIVE, A SECOND FLUORESCENT DYE, AND A CHELATING AGENT | TOA MEDICAL ELECTRONICS CO., LTD. (JP) | 1999-04-06 | — | — | US | claimed |
| EP-0708334-B1 | Reagent and method for analyzing solid components in urine | SYSMEX CORP (JP) | 2001-05-23 | — | — | EP | disclosed |
| EP-0613003-B1 | A reagent for detecting malaria infected cells and a detecting method for malaria infected cells using the same | SYSMEX CORP (JP) | 2000-04-26 | — | — | EP | disclosed |
| US-5891733-A | COMPRISING A BUFFER AGENT, AN OSMOTIC PRESSURE COMPENSATING AGENT,A FIRST DYE WHICH IS A CONDENSED BENZENE DERIVATIVE, A SECOND FLUORESCENT DYE, AND A CHELATING AGENT | TOA MEDICAL ELECTRONICS CO., LTD. (JP) | 1999-04-06 | — | — | US | disclosed |
| EP-0708334-A2 | Reagent and method for analyzing solid components in urine | TOA MEDICAL ELECTRONICS CO., LTD. (JP) | 1996-04-24 | — | — | EP | disclosed |
| US-5470751-A | Reagent for detecting malaria infected cells and a detecting method for malaria infected cells using the same | TOA MEDICAL ELECTRONICS CO., LTD. (JP) | 1995-11-28 | — | — | US | disclosed |
| EP-0613003-A1 | A reagent for detecting malaria infected cells and a detecting method for malaria infected cells using the same | TOA MEDICAL ELECTRONICS CO., LTD. (JP) | 1994-08-31 | — | — | EP | disclosed |