Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 9/20 | 0.61 |
| ▸ | APP | P05067 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 7/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.49 |
| ▸ | LMNA | P02545 | 6/20 | 0.49 |
| ▸ | HTT | P42858 | 6/20 | 0.49 |
| ▸ | MMP14 | P50281 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | THRB | P10828 | 5/20 | 0.48 |
| ▸ | RECQL | P46063 | 3/20 | 0.48 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.48 |
| ▸ | VDR | P11473 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | ALPG | P10696 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6128356 | 0.99 | MAPT (0.60) | MAPTAPPMEN1KMT2ALMNA | |
| Iodide SCHEMBL7758714 | 0.88 | MAPT (0.62) | MAPTAPPMEN1KMT2ALMNA | |
| Iodide SCHEMBL7758713 | 0.88 | MAPT (0.62) | MAPTAPPMEN1KMT2ALMNA | |
| SCHEMBL25664248 | 0.87 | MAPT (0.72) | MAPTAPPMEN1KMT2ALMNA | |
| Iodide SCHEMBL29249905 | 0.87 | MAPT (0.70) | MAPTAPPMEN1KMT2ALMNA | |
| SCHEMBL13245094 | 0.86 | MAPT (0.62) | MAPTAPPMEN1KMT2ALMNA | |
| SCHEMBL10035982 | 0.86 | MAPT (0.62) | MAPTAPPMEN1KMT2ALMNA | |
| SCHEMBL16253381 | 0.86 | MAPT (0.68) | MAPTAPPMEN1KMT2ALMNA | |
| SCHEMBL8995923 | 0.86 | MAPT (0.68) | MAPTAPPMEN1KMT2ALMNA | |
| Hydrochloric Acid SCHEMBL14675272 | 0.85 | MAPT (0.67) | MAPTAPPMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105837558-A | Reagent and method for fluorescence detection of hypochlorous acid | 山西大学 | 2016-08-10 | — | — | CN | disclosed |
| CN-105777607-A | Triphenylamine bis-indolyl iodised salt as well as synthesis method and application thereof | 山西大学 | 2016-07-20 | — | — | CN | disclosed |