Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.52 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11637883 | 0.78 | KDM4E (0.53) | POLBMCHR1KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL17166506 | 0.75 | SMN1; SMN2 (0.59) | PTGER4KDM4EALDH1A1NPC1MEN1 | |
| SCHEMBL18830189 | 0.75 | PTGER4 (0.53) | POLBPTGER4KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL8161809 | 0.75 | MEN1 (0.53) | POLBKDM4EHSD17B10ALDH1A1NPC1 | |
| SCHEMBL3764360 | 0.74 | PTGER4 (0.70) | PTGER4KDM4EHSD17B10ALDH1A1NPC1 | |
| SCHEMBL18830370 | 0.74 | PTGER4 (0.61) | POLBPTGER4KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL18433144 | 0.73 | PTGER4 (0.49) | PTGER4KDM4EALDH1A1NPC1EPHX2 | |
| SCHEMBL12316323 | 0.73 | HTT (0.53) | POLBPTGER4KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL4193304 | 0.73 | POLB (0.74) | POLBALDH1A1NPC1RAB9AMEN1 | |
| SCHEMBL22452600 | 0.73 | MTNR1A (0.45) | POLBMCHR1KDM4EHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1091947-A1 | ALPHA-(1-PIPERAZINYL)ACETAMIDO ARENECARBOXYLIC ACID DERIVATIVES AS ANTIDIABETIC AGENTS | MERCK PATENT GmbH (DE) | 2001-04-18 | — | — | EP | disclosed |
| WO-1999064407-A1 | α-(1-PIPERAZINYL)ACETAMIDO ARENECARBOXYLIC ACID DERIVATIVES AS ANTIDIABETIC AGENTS | MERCK PATENT GMBH (DE) | 1999-12-16 | — | — | WO | disclosed |
| WO-1999031096-A1 | PIPERAZINE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTS | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | disclosed |