SCHEMBL7759652

SCHEMBL7759652

CC(C)(C)C(=O)OCCOC(=O)Oc1ccc([N+](=O)[O-])cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 1/20 0.53
GAA P10253 1/20 0.52
BCL9 O00512 1/20 0.50
CTNNB1 P35222 1/20 0.50
MAPT P10636 4/20 0.46
CRHBP P24387 1/20 0.45
CRHR2 Q13324 1/20 0.45
MGLL Q99685 2/20 0.45
NR1H4 Q96RI1 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
ALDH1A1 P00352 4/20 0.43
CYP3A4 P08684 2/20 0.43
CYP1A2 P05177 1/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
PKM P14618 1/20 0.43
KMT2A Q03164 1/20 0.43
LMNA P02545 1/20 0.42
TP53 P04637 1/20 0.42
THRB P10828 1/20 0.42
MAPK1 P28482 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25863 0.89 HTR2A (0.53) HTR2AGAABCL9CTNNB1MAPT
SCHEMBL409598 0.88 HTR2A (0.59) HTR2AGAABCL9CTNNB1MAPT
SCHEMBL30967402 0.88 HTR2A (0.52) HTR2AGAABCL9CTNNB1MAPT
SCHEMBL7080623 0.86 HTR2A (0.53) HTR2AGAABCL9CTNNB1MAPT
SCHEMBL409084 0.84 HTR2A (0.56) HTR2AGAABCL9CTNNB1MAPT
SCHEMBL4433836 0.84 HTR2A (0.56) HTR2AGAABCL9CTNNB1MAPT
SCHEMBL125510 0.84 HTR2A (0.56) HTR2AGAABCL9CTNNB1MAPT
SCHEMBL10062010 0.84 HTR2A (0.56) HTR2AGAABCL9CTNNB1MAPT
SCHEMBL2615571 0.83 HTR2A (0.48) HTR2AGAABCL9CTNNB1MAPT
SCHEMBL2597400 0.82 BCL9 (0.63) HTR2AGAABCL9CTNNB1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3860999-A1 DERIVATIVES OF RELEBACTAM AND USES THEREOF Arixa Pharmaceuticals, Inc. (US) 2021-08-11 EP disclosed
WO-2020072442-A1 DERIVATIVES OF RELEBACTAM AND USES THEREOF ARIXA PHARMACEUTICALS, INC. (US) 2020-04-09 WO disclosed
WO-2001062242-A1 PRODRUGS OF SUBSTITUTED CYCLOPENTANE AND CYCLOPENTENE COMPOUNDS USEFUL AS NEURAMINIDASE INHIBITORS BIOCRYST PHARMACEUTICALS, INC. (US) 2001-08-30 WO disclosed
US-5789595-A ANTICOAGULANTS TERUMO KABUSHIKI KAISHA (JP) 1998-08-04 US disclosed
EP-0790247-A1 TETRAHYDROISOQUINOLINE DERIVATIVE AND MEDICINAL PREPARATION CONTAINING THE SAME TERUMO KABUSHIKI KAISHA (JP) 1997-08-20 EP disclosed