SCHEMBL7759761

SCHEMBL7759761

Cc1cc2c(cc1C1(c3cccc(C(=O)C=CN4CCOCC4)c3)CC1)C(C)(C)CCC2(C)C

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RXRA P19793 11/20 0.47
MAPT P10636 8/20 0.45
ALDH1A1 P00352 5/20 0.45
USP2 O75604 4/20 0.45
ALOX12 P18054 3/20 0.45
NPC1 O15118 6/20 0.44
RAB9A P51151 6/20 0.44
SMN1; SMN2 Q16637 3/20 0.44
HPGD P15428 2/20 0.44
MEN1 O00255 2/20 0.44
MAPK1 P28482 2/20 0.44
KMT2A Q03164 2/20 0.44
POLB P06746 1/20 0.44
HSP90AA1 P07900 1/20 0.44
RXRG P48443 8/20 0.40
RXRB P28702 7/20 0.40
RARG P13631 4/20 0.39
RARB P10826 3/20 0.39
RARA P10276 2/20 0.39
PPARG P37231 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7760220 0.88 RXRA (0.48) RXRAMAPTALDH1A1USP2ALOX12
SCHEMBL7756697 0.83 MAPT (0.43) RXRAMAPTALDH1A1USP2ALOX12
SCHEMBL7756689 0.77 RXRA (0.44) RXRAMAPTALDH1A1USP2ALOX12
SCHEMBL7759767 0.77 ALDH1A1 (0.51) RXRAALDH1A1NPC1RAB9ASMN1; SMN2
SCHEMBL7762869 0.71 KDM4E (0.50) RXRAALDH1A1NPC1RAB9ASMN1; SMN2
SCHEMBL7760238 0.70 RXRA (0.56) RXRARXRGRXRBRARGRARB
SCHEMBL7760236 0.70 RXRA (0.56) RXRARXRGRXRBRARGRARB
SCHEMBL28966167 0.69 ALDH1A1 (0.82) MAPTALDH1A1USP2ALOX12NPC1
SCHEMBL7762990 0.69 RXRA (0.68) RXRAMEN1KMT2ARXRGRXRB
SCHEMBL7761535 0.69 RXRA (0.52) RXRARXRGRXRBRARGRARB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6258775-B1 3-(3-(5,5,8,8-TETRAMATHYL-5,6,7,8-TETRAHYDRO-2-NAPHTYLCARBONYL )PHENYL)ACRYLIC ACID FOR TREATING DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 2001-07-10 US claimed
EP-0915823-B1 BI-AROMATIC COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME AND USES CT INTERNAT DE (FR) 2001-04-18 EP claimed
US-6258775-B1 3-(3-(5,5,8,8-TETRAMATHYL-5,6,7,8-TETRAHYDRO-2-NAPHTYLCARBONYL )PHENYL)ACRYLIC ACID FOR TREATING DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 2001-07-10 US disclosed
EP-0915823-B1 BI-AROMATIC COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME AND USES CT INTERNAT DE (FR) 2001-04-18 EP disclosed
EP-0915823-A1 BI-AROMATIC COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME AND USES CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA - CIRD GALDERMA (FR) 1999-05-19 EP disclosed
WO-1998022423-A1 BI-AROMATIC COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME AND USES CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) (FR) 1998-05-28 WO disclosed