SCHEMBL7759870

SCHEMBL7759870

Cc1cc2c(cc1C(NO)c1ccccc1C=CC(=O)O)C(C)(C)CCC2(C)C

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RXRA P19793 14/20 0.47
RARA P10276 5/20 0.43
RARG P13631 5/20 0.43
RARB P10826 4/20 0.43
CYP26A1 O43174 2/20 0.43
HNF4A P41235 2/20 0.42
CYP3A4 P08684 1/20 0.42
CYP26B1 Q9NR63 1/20 0.40
RXRG P48443 5/20 0.39
RXRB P28702 5/20 0.38
HDAC3 O15379 1/20 0.36
HDAC4 P56524 1/20 0.36
HDAC1 Q13547 1/20 0.36
HDAC7 Q8WUI4 1/20 0.36
HDAC2 Q92769 1/20 0.36
HDAC10 Q969S8 1/20 0.36
HDAC11 Q96DB2 1/20 0.36
HDAC8 Q9BY41 1/20 0.36
HDAC6 Q9UBN7 1/20 0.36
HDAC9 Q9UKV0 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7759787 0.85 RXRA (0.54) RXRARARARARGRARBCYP26A1
SCHEMBL7759790 0.85 RXRA (0.54) RXRARARARARGRARBCYP26A1
SCHEMBL7759725 0.85 CYP26A1 (0.48) RXRARARARARGRARBCYP26A1
SCHEMBL7756631 0.82 RXRA (0.52) RXRARARARARGRARBCYP26A1
SCHEMBL7889498 0.82 RXRA (0.52) RXRARARARARGRARBCYP26A1
SCHEMBL7756680 0.74 RXRA (0.54) RXRARARARARGRARBCYP26A1
SCHEMBL7756683 0.74 RXRA (0.54) RXRARARARARGRARBCYP26A1
SCHEMBL7879838 0.74 RARG (0.62) RXRARARARARGRARBCYP26A1
SCHEMBL7879841 0.74 RARG (0.62) RXRARARARARGRARBCYP26A1
SCHEMBL7761215 0.74 RXRA (0.52) RXRARARARARGRARBCYP26A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6258775-B1 3-(3-(5,5,8,8-TETRAMATHYL-5,6,7,8-TETRAHYDRO-2-NAPHTYLCARBONYL )PHENYL)ACRYLIC ACID FOR TREATING DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 2001-07-10 US claimed
EP-0915823-B1 BI-AROMATIC COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME AND USES CT INTERNAT DE (FR) 2001-04-18 EP claimed
US-6258775-B1 3-(3-(5,5,8,8-TETRAMATHYL-5,6,7,8-TETRAHYDRO-2-NAPHTYLCARBONYL )PHENYL)ACRYLIC ACID FOR TREATING DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 2001-07-10 US disclosed