SCHEMBL7760178

SCHEMBL7760178

CC(C)(C)[Si](NC(=O)N[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)(c1ccccc1)c1ccccc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 1/20 0.37
HDAC4 P56524 1/20 0.37
HDAC1 Q13547 1/20 0.37
HDAC7 Q8WUI4 1/20 0.37
HDAC2 Q92769 1/20 0.37
HDAC10 Q969S8 1/20 0.37
HDAC11 Q96DB2 1/20 0.37
HDAC8 Q9BY41 1/20 0.37
HDAC6 Q9UBN7 1/20 0.37
HDAC9 Q9UKV0 1/20 0.37
HDAC5 Q9UQL6 1/20 0.37
TSHR P16473 2/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
TP53 P04637 1/20 0.35
EPHX1 P07099 1/20 0.35
EPHX2 P34913 1/20 0.35
CDK9 P50750 1/20 0.35
CLK4 Q9HAZ1 1/20 0.35
KMT2A Q03164 4/20 0.35
MAPT P10636 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9095282 0.85 MAPT (0.41) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL6282747 0.77 HDAC3 (0.36) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL841941 0.76 TAAR1 (0.34) HDAC3HDAC4HDAC1HDAC7HDAC2
Hydrochloric Acid SCHEMBL23928399 0.75 HDAC3 (0.35) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL7763785 0.72 ESR1 (0.40) TSHRSMN1; SMN2TP53EPHX1EPHX2
SCHEMBL7761636 0.72 TSHR (0.42) HDAC3HDAC1HDAC7HDAC2HDAC8
SCHEMBL31307613 0.71 MME (0.40) MAPTKDM4EALDH1A1
SCHEMBL22266027 0.71 KEAP1 (0.41) KMT2AALDH1A1POLB
SCHEMBL564254 0.69 ESR1 (0.34) HDAC3HDAC4HDAC1HDAC7HDAC2
SCHEMBL31078096 0.68 MAPT (0.39) HDAC3HDAC4HDAC1HDAC7HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1092714-A2 Process for the synthesis of benzo[b]thiophenes Eli Lilly & Company (US) 2001-04-18 EP disclosed
EP-0830355-A4 PROCESS FOR THE SYNTHESIS OF BENZO(b)THIOPHENES LILLY CO ELI (US) 1998-09-30 EP disclosed
EP-0830362-A4 PROCESS FOR THE SYNTHESIS OF VINYL SULFENIC ACID DERIVATIVES LILLY CO ELI (US) 1998-09-02 EP disclosed
EP-0830355-A1 PROCESS FOR THE SYNTHESIS OF BENZO(b)THIOPHENES ELI LILLY AND COMPANY (US) 1998-03-25 EP disclosed
EP-0830362-A1 PROCESS FOR THE SYNTHESIS OF VINYL SULFENIC ACID DERIVATIVES ELI LILLY AND COMPANY (US) 1998-03-25 EP disclosed
US-5606075-A CYCLIZATION IN THE PRESENCE OF AN ACID CATALYST ELI LILLY AND COMPANY (US) 1997-02-25 US disclosed
WO-1996040677-A1 PROCESS FOR THE SYNTHESIS OF BENZO[b]THIOPHENES ELI LILLY AND COMPANY (US) 1996-12-19 WO disclosed
WO-1996040693-A1 PROCESS FOR THE SYNTHESIS OF VINYL SULFENIC ACID DERIVATIVES ELI LILLY AND COMPANY (US) 1996-12-19 WO disclosed
US-5512701-A REACTING SULFOXIDE DERIVATIVE WITH A SILYATING AGENT TO FORM SULFENATE SILYL ESTER, OPTIONALLY REACTING INTERMEDIATE WITH AN AMINE AND/OR A MERCAPTAN ELI LILLY AND COMPANY (US) 1996-04-30 US disclosed