Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.37 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6746851 | 0.84 | HSD17B10 (0.45) | ESR1ESR2MAPTTSHREPHX1 | |
| SCHEMBL7761358 | 0.83 | ALDH1A1 (0.39) | ESR1ESR2MAPTTSHRCES2 | |
| SCHEMBL7761636 | 0.76 | TSHR (0.42) | MAPTSMN1; SMN2TSHRTP53EPHX1 | |
| SCHEMBL7760178 | 0.72 | HDAC3 (0.37) | MAPTSMN1; SMN2TSHRTP53EPHX1 | |
| SCHEMBL842862 | 0.72 | ESR1 (0.42) | ESR1ESR2MAPTSMN1; SMN2TSHR | |
| SCHEMBL17830152 | 0.70 | ESR1 (0.41) | ESR1ESR2MAPTTSHRNR1H2 | |
| SCHEMBL8646495 | 0.70 | KMT2A (0.39) | ESR1ESR2MAPTTSHRCES2 | |
| SCHEMBL31425696 | 0.69 | ESR1 (0.39) | ESR1ESR2MAPTTSHRNR1H2 | |
| SCHEMBL16706156 | 0.69 | ESR1 (0.44) | ESR1ESR2MAPTSMN1; SMN2TSHR | |
| SCHEMBL9937737 | 0.69 | ESR1 (0.44) | ESR1ESR2MAPTSMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1092714-A2 | Process for the synthesis of benzo[b]thiophenes | Eli Lilly & Company (US) | 2001-04-18 | — | — | EP | disclosed |
| US-5606075-A | CYCLIZATION IN THE PRESENCE OF AN ACID CATALYST | ELI LILLY AND COMPANY (US) | 1997-02-25 | — | — | US | disclosed |
| US-5514826-A | INTERMEDIATES FOR 2-ARYLBENZO(B)THIOPHENES | ELI LILLY AND COMPANY (US) | 1996-05-07 | — | — | US | disclosed |
| US-5512701-A | REACTING SULFOXIDE DERIVATIVE WITH A SILYATING AGENT TO FORM SULFENATE SILYL ESTER, OPTIONALLY REACTING INTERMEDIATE WITH AN AMINE AND/OR A MERCAPTAN | ELI LILLY AND COMPANY (US) | 1996-04-30 | — | — | US | disclosed |