Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 3/20 | 0.60 |
| ▸ | RXRA | P19793 | 15/20 | 0.60 |
| ▸ | RXRB | P28702 | 7/20 | 0.60 |
| ▸ | RARA | P10276 | 6/20 | 0.60 |
| ▸ | RARB | P10826 | 6/20 | 0.60 |
| ▸ | RARG | P13631 | 6/20 | 0.60 |
| ▸ | RXRG | P48443 | 6/20 | 0.60 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7760701 | 1.00 | CYP26A1 (0.60) | CYP26A1RXRARXRBRARARARB | |
| SCHEMBL7760231 | 0.89 | RXRA (0.61) | CYP26A1RXRARXRBRARARARB | |
| SCHEMBL7760227 | 0.89 | RXRA (0.61) | CYP26A1RXRARXRBRARARARB | |
| SCHEMBL7900823 | 0.88 | RXRA (0.53) | CYP26A1RXRARXRBRARARARB | |
| SCHEMBL7900821 | 0.88 | RXRA (0.53) | CYP26A1RXRARXRBRARARARB | |
| SCHEMBL7758834 | 0.87 | CYP26A1 (0.79) | CYP26A1RXRARXRBRARARARB | |
| SCHEMBL7758836 | 0.87 | CYP26A1 (0.79) | CYP26A1RXRARXRBRARARARB | |
| SCHEMBL7762885 | 0.87 | RXRA (0.63) | CYP26A1RXRARXRBRARARARB | |
| SCHEMBL7759739 | 0.87 | RXRA (0.63) | CYP26A1RXRARXRBRARARARB | |
| SCHEMBL6906197 | 0.81 | RXRA (0.79) | CYP26A1RXRARXRBRARARARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258775-B1 | 3-(3-(5,5,8,8-TETRAMATHYL-5,6,7,8-TETRAHYDRO-2-NAPHTYLCARBONYL )PHENYL)ACRYLIC ACID FOR TREATING DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2001-07-10 | — | — | US | claimed |
| EP-0915823-B1 | BI-AROMATIC COMPOUNDS, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING SAME AND USES | CT INTERNAT DE (FR) | 2001-04-18 | — | — | EP | claimed |
| US-6258775-B1 | 3-(3-(5,5,8,8-TETRAMATHYL-5,6,7,8-TETRAHYDRO-2-NAPHTYLCARBONYL )PHENYL)ACRYLIC ACID FOR TREATING DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2001-07-10 | — | — | US | disclosed |