Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 16/20 | 0.53 |
| ▸ | RXRB | P28702 | 7/20 | 0.53 |
| ▸ | RXRG | P48443 | 7/20 | 0.53 |
| ▸ | RARA | P10276 | 6/20 | 0.53 |
| ▸ | RARB | P10826 | 6/20 | 0.53 |
| ▸ | RARG | P13631 | 6/20 | 0.53 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7900821 | 1.00 | RXRA (0.53) | RXRARXRBRXRGRARARARB | |
| SCHEMBL7760701 | 0.88 | CYP26A1 (0.60) | RXRARXRBRXRGRARARARB | |
| SCHEMBL7760698 | 0.88 | CYP26A1 (0.60) | RXRARXRBRXRGRARARARB | |
| SCHEMBL7899449 | 0.88 | CYP26A1 (0.60) | RXRARXRBRXRGRARARARB | |
| SCHEMBL7899451 | 0.88 | CYP26A1 (0.60) | RXRARXRBRXRGRARARARB | |
| SCHEMBL7872275 | 0.83 | CYP26A1 (0.51) | RXRARXRBRXRGRARARARB | |
| SCHEMBL7872280 | 0.83 | CYP26A1 (0.51) | RXRARXRBRXRGRARARARB | |
| SCHEMBL6901737 | 0.80 | RXRA (0.61) | RXRARXRBRXRGRARARARB | |
| SCHEMBL7756555 | 0.79 | RXRA (0.53) | RXRARXRBRXRGRARARARB | |
| SCHEMBL7756564 | 0.79 | RXRA (0.53) | RXRARXRBRXRGRARARARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258775-B1 | 3-(3-(5,5,8,8-TETRAMATHYL-5,6,7,8-TETRAHYDRO-2-NAPHTYLCARBONYL )PHENYL)ACRYLIC ACID FOR TREATING DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2001-07-10 | — | — | US | disclosed |