Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | HTT | P42858 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 5/20 | 0.32 |
| ▸ | RAB9A | P51151 | 5/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diethylamine SCHEMBL7761052 | 0.90 | MEN1 (0.36) | ALDH1A1HTTMAPTL3MBTL1KMT2A | |
| SCHEMBL7760980 | 0.88 | LCK (0.41) | AURKAALDH1A1HTTMAPTHPGD | |
| Diethylamine SCHEMBL7760962 | 0.86 | RIPK1 (0.36) | ALDH1A1MAPTHPGDALOX12KMT2A | |
| Diethylamine SCHEMBL9400388 | 0.86 | F2R (0.39) | ALDH1A1HPGDKMT2AMEN1NPC1 | |
| Diethylamine SCHEMBL9400390 | 0.86 | KMT2A (0.41) | ALDH1A1HTTMAPTHPGDL3MBTL1 | |
| Diethylamine SCHEMBL7759248 | 0.83 | MAPT (0.40) | ALDH1A1MAPTHPGDALOX12KDM4E | |
| Diethylamine SCHEMBL9400483 | 0.83 | PPARG (0.35) | ALDH1A1HTTMAPTHPGDL3MBTL1 | |
| Diethylamine SCHEMBL7761090 | 0.82 | SMN1; SMN2 (0.41) | ALDH1A1HTTMAPTHPGDTDP1 | |
| Diethylamine SCHEMBL7761030 | 0.82 | MEN1 (0.36) | ALDH1A1HTTMAPTL3MBTL1KDM4E | |
| Diethylamine SCHEMBL9400383 | 0.82 | LMNA (0.39) | ALDH1A1HTTMAPTHPGDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0665462-B1 | Thermofixable photosensitive recording material and process for preparing thereof | NEW OJI PAPER CO LTD (JP) | 2001-04-18 | — | — | EP | disclosed |
| US-5565306-A | SUBSTRATE HAVING RECORDING LAYER CONTAINING PYRAZOLONE DERIVATIVE, HYDROQUINONE DERIVATIVE, ACIDIC SUBSTANCE MUTUALLY DISSOLVED THEREIN | NEW OJI PAPER CO., LTD. (JP) | 1996-10-15 | — | — | US | disclosed |
| EP-0665462-A1 | Thermofixable photosensitive recording material and process for preparing thereof | NEW OJI PAPER CO., LTD. (JP) | 1995-08-02 | — | — | EP | disclosed |
| US-5372917-A | Excellent color forming property, storage stability and recorded image preservability; pyrazolone derivatives | KANZAKI PAPER MANUFACTURING CO., LTD. (JP) | 1994-12-13 | — | — | US | disclosed |