Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | GUSB | P08236 | 1/20 | 0.45 |
| ▸ | HPSE | Q9Y251 | 3/20 | 0.43 |
| ▸ | RECQL | P46063 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.42 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.41 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7760514 | 0.86 | CHEK2 (0.56) | MAPTHDAC6GUSBRECQLBLM | |
| SCHEMBL7756164 | 0.85 | ALOX5 (0.55) | MAPTHDAC6GUSBMEN1KMT2A | |
| SCHEMBL7756156 | 0.84 | HDAC6 (0.49) | MAPTHDAC6GUSBRECQLBLM | |
| SCHEMBL7760718 | 0.83 | HDAC6 (0.52) | MAPTHDAC6ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL9166025 | 0.82 | MAPT (0.53) | MAPTHDAC6GUSBRECQLBLM | |
| SCHEMBL318730 | 0.81 | HDAC6 (0.67) | HDAC6PTPN5CHEK2SCD | |
| SCHEMBL6578557 | 0.80 | MAPT (0.47) | MAPTHDAC6GUSBHPSEALDH1A1 | |
| SCHEMBL25808586 | 0.78 | HDAC6 (0.59) | MAPTHDAC6HPSEMEN1KMT2A | |
| SCHEMBL7759314 | 0.78 | HDAC6 (0.66) | MAPTHDAC6RECQLBLMMEN1 | |
| SCHEMBL7760694 | 0.77 | SMN1; SMN2 (0.57) | MAPTHDAC6MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579827-B1 | METHOD OF PREPARING 2-ARYLBENZIMIDAZOLE 5-SULPHONIC ACIDS | MERCK PATENT GMBH (DE) | 2001-04-18 | — | — | EP | disclosed |
| US-5473079-A | Process for preparing 2-arylbenzimidazole-5-sulfonic acids | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-12-05 | — | — | US | disclosed |