Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 18/20 | 0.76 |
| ▸ | ITGAV | P06756 | 18/20 | 0.76 |
| ▸ | ITGA2B | P08514 | 18/20 | 0.76 |
| ▸ | ITGB1 | P05556 | 10/20 | 0.76 |
| ▸ | ITGB5 | P18084 | 10/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7345191 | 0.86 | ITGB3 (1.00) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7370505 | 0.81 | ITGB3 (0.71) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7495445 | 0.81 | ITGB3 (1.00) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7495439 | 0.81 | ITGB3 (1.00) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL30073956 | 0.79 | ITGB3 (0.63) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL6225428 | 0.79 | ITGB3 (0.63) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL25605068 | 0.77 | ADRA2A (0.63) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7500788 | 0.76 | ITGB3 (1.00) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7494201 | 0.76 | ITGB3 (1.00) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7500781 | 0.76 | ITGB3 (1.00) | ITGB3ITGAVITGA2BITGB1ITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889875-B1 | CYCLOPROPYL ALKANOIC ACID DERIVATIVES | SEARLE & CO (US) | 2001-06-20 | — | — | EP | claimed |