SCHEMBL7762444

SCHEMBL7762444

Fc1cc(OCC2CC[SiH](Cl)CC2)cc(F)c1F

nearest known ligand 0.40

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PARP10 Q53GL7 2/20 0.40
PARP15 Q460N3 1/20 0.40
TRPV4 Q9HBA0 1/20 0.33
SCN9A Q15858 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7762468 0.91 PARP10 (0.36) PARP10PARP15TRPV4SCN9A
SCHEMBL7762470 0.91 PARP10 (0.36) PARP10PARP15TRPV4SCN9A
SCHEMBL7762475 0.91 PARP10 (0.36) PARP10PARP15TRPV4SCN9A
SCHEMBL7760303 0.89 PARP10 (0.39) PARP10PARP15TRPV4
SCHEMBL7760369 0.84 PARP10 (0.47) PARP10PARP15TRPV4SCN9A
SCHEMBL7761393 0.82 PARP10 (0.45) PARP10PARP15TRPV4SCN9A
SCHEMBL7760269 0.79 SIGMAR1 (0.46)
SCHEMBL7757312 0.77 PARP10 (0.43) PARP10PARP15TRPV4SCN9A
SCHEMBL7757324 0.77 PARP10 (0.43) PARP10PARP15TRPV4SCN9A
SCHEMBL7757316 0.77 PARP10 (0.43) PARP10PARP15TRPV4SCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0714899-B1 Novel silacyclohexane compounds, preparation thereof, liquid crystal compositions comprising the same, and liquid crystal devices comprising the compositions SHINETSU CHEMICAL CO (JP) 2001-04-18 EP disclosed
US-5641430-A Silacyclohexane compounds, preparation thereof, liquid crystal compositions comprising the same, and liquid crystal devices comprising the compositions SHIN-ETSU CHEMICAL CO., LTD. (JP) 1997-06-24 US disclosed
EP-0714899-A1 Novel silacyclohexane compounds, preparation thereof, liquid crystal compositions comprising the same, and liquid crystal devices comprising the compositions SHIN-ETSU CHEMICAL CO., LTD. (JP) 1996-06-05 EP disclosed