SCHEMBL7762450

SCHEMBL7762450

CC(C)CCC1CCC([SiH]2CCC(COc3cc(F)c(Cl)c(F)c3)CC2)CC1

nearest known ligand 0.33

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 3/20 0.33
ACACB O00763 5/20 0.32
PDK2 Q15119 1/20 0.32
SCN9A Q15858 1/20 0.31
P2RX3 P56373 1/20 0.31
P2RX2 Q9UBL9 1/20 0.31
PARP10 Q53GL7 2/20 0.31
PARP15 Q460N3 1/20 0.31
ACACA Q13085 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7762438 1.00 CNR2 (0.33) CNR2ACACBPDK2SCN9AP2RX3
SCHEMBL7762443 1.00 CNR2 (0.33) CNR2ACACBPDK2SCN9AP2RX3
SCHEMBL7761349 0.81 PARP10 (0.33) ACACBP2RX3P2RX2PARP10PARP15
SCHEMBL7761355 0.81 PARP10 (0.33) ACACBP2RX3P2RX2PARP10PARP15
SCHEMBL7760303 0.75 PARP10 (0.39) PDK2PARP10PARP15
SCHEMBL7757416 0.69 DRD2 (0.39) PARP10PARP15
SCHEMBL7757408 0.69 DRD2 (0.39) PARP10PARP15
SCHEMBL7757400 0.69 DRD2 (0.39) PARP10PARP15
SCHEMBL8579081 0.66
SCHEMBL8579086 0.66

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0714899-B1 Novel silacyclohexane compounds, preparation thereof, liquid crystal compositions comprising the same, and liquid crystal devices comprising the compositions SHINETSU CHEMICAL CO (JP) 2001-04-18 EP disclosed
US-5641430-A Silacyclohexane compounds, preparation thereof, liquid crystal compositions comprising the same, and liquid crystal devices comprising the compositions SHIN-ETSU CHEMICAL CO., LTD. (JP) 1997-06-24 US disclosed
EP-0714899-A1 Novel silacyclohexane compounds, preparation thereof, liquid crystal compositions comprising the same, and liquid crystal devices comprising the compositions SHIN-ETSU CHEMICAL CO., LTD. (JP) 1996-06-05 EP disclosed