Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 2/20 | 0.60 |
| ▸ | EGFR | P00533 | 9/20 | 0.57 |
| ▸ | RAF1 | P04049 | 5/20 | 0.57 |
| ▸ | BRAF | P15056 | 5/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.55 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
| ▸ | KIF5B | P33176 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.54 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL641359 | 0.88 | EGFR (0.75) | EGFRRAF1BRAFERBB2KDR | |
| Hydrochloric Acid SCHEMBL7760887 | 0.83 | EGFR (0.76) | EGFRERBB2DYRK1A | |
| SCHEMBL13599953 | 0.80 | RAF1 (0.79) | ALKEGFRRAF1BRAFERBB2 | |
| SCHEMBL4738585 | 0.80 | EGFR (0.80) | EGFRRAF1BRAFERBB2GLA | |
| SCHEMBL8104967 | 0.78 | EGFR (0.57) | EGFRERBB2DYRK1A | |
| SCHEMBL7766632 | 0.78 | EGFR (0.57) | EGFRRAF1BRAFERBB2RIPK2 | |
| Hydrochloric Acid SCHEMBL7763512 | 0.77 | ALK (0.69) | ALKEGFRNOD1ABCG2HTT | |
| SCHEMBL9478 | 0.77 | EGFR (0.77) | ALKEGFRRAF1BRAFERBB2 | |
| Hydrochloric Acid SCHEMBL8104687 | 0.77 | EGFR (0.70) | EGFRERBB2 | |
| SCHEMBL3664557 | 0.77 | EGFR (0.81) | ALKEGFRRAF1BRAFERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0824525-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-06-13 | — | — | EP | disclosed |
| US-5932574-A | ANTICANCER AGENT | ZENECA LIMITED (GB) | 1999-08-03 | — | — | US | disclosed |
| EP-0824525-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1998-02-25 | — | — | EP | disclosed |
| WO-1996033977-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-10-31 | — | — | WO | disclosed |