Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.77 |
| ▸ | KDR | P35968 | 8/20 | 0.77 |
| ▸ | RET | P07949 | 7/20 | 0.77 |
| ▸ | KIF5B | P33176 | 6/20 | 0.77 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.77 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.77 |
| ▸ | FBP1 | P09467 | 2/20 | 0.66 |
| ▸ | CLK1 | P49759 | 2/20 | 0.66 |
| ▸ | AURKA | O14965 | 1/20 | 0.66 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.66 |
| ▸ | INSR | P06213 | 1/20 | 0.66 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.66 |
| ▸ | FLT4 | P35916 | 1/20 | 0.66 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.66 |
| ▸ | TEK | Q02763 | 1/20 | 0.66 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.66 |
| ▸ | BRAF | P15056 | 3/20 | 0.65 |
| ▸ | RAF1 | P04049 | 2/20 | 0.65 |
| ▸ | JAK3 | P52333 | 2/20 | 0.63 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14515606 | 0.90 | KDR (0.72) | EGFRKDRRETKIF5BRIPK2 | |
| SCHEMBL8383 | 0.90 | EGFR (0.83) | EGFRKDRRETKIF5BRIPK2 | |
| SCHEMBL30124192 | 0.90 | EGFR (0.83) | EGFRKDRRETKIF5BRIPK2 | |
| SCHEMBL29679736 | 0.90 | EGFR (0.83) | EGFRKDRRETKIF5BRIPK2 | |
| Hydrochloric Acid SCHEMBL28040041 | 0.89 | EGFR (0.81) | EGFRKDRRETKIF5BRIPK2 | |
| SCHEMBL14964757 | 0.88 | EGFR (0.81) | EGFRKDRRETKIF5BRIPK2 | |
| Hydrochloric Acid SCHEMBL27915151 | 0.88 | EGFR (0.80) | EGFRKDRRETKIF5BRIPK2 | |
| SCHEMBL22630829 | 0.88 | EGFR (0.69) | EGFRKDRRETKIF5BRIPK2 | |
| SCHEMBL643039 | 0.87 | EGFR (0.84) | EGFRKDRRETKIF5BRIPK2 | |
| SCHEMBL5864719 | 0.87 | KDR (0.82) | EGFRKDRRETKIF5BRIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0823900-B1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-12-27 | — | — | EP | disclosed |
| US-5770599-A | RECEPTOR TYROSINE KINASE INHIBITORS including 4-(3'-chloro-4'-fluoroanilino)-7-methoxy-6-(2-morpholinoethoxy)quinazoline (gefitinib) | ZENECA LIMITED (GB) | 1998-06-23 | — | — | US | disclosed |
| EP-0823900-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1998-02-18 | — | — | EP | disclosed |
| WO-1996033980-A1 | QUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-10-31 | — | — | WO | disclosed |