Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.52 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.48 |
| ▸ | FBP1 | P09467 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7763519 | 0.86 | EGFR (0.56) | EGFRDYRK1AERBB2FBP1 | |
| SCHEMBL8103025 | 0.81 | EGFR (0.61) | EGFRERBB2ERBB4 | |
| SCHEMBL8103000 | 0.78 | EGFR (0.65) | EGFRERBB2ERBB4 | |
| SCHEMBL7763004 | 0.78 | ALK (0.60) | EGFRDYRK1AERBB2 | |
| Hydrochloric Acid SCHEMBL7760887 | 0.78 | EGFR (0.76) | EGFRDYRK1AERBB2 | |
| Hydrochloric Acid SCHEMBL8104687 | 0.77 | EGFR (0.70) | EGFRERBB2ERBB4 | |
| SCHEMBL7760849 | 0.76 | EGFR (0.68) | EGFRERBB2FBP1 | |
| SCHEMBL7763501 | 0.74 | EGFR (0.66) | EGFRERBB2FBP1 | |
| SCHEMBL7764438 | 0.74 | EGFR (0.62) | EGFRERBB2ERBB4FBP1 | |
| SCHEMBL7766632 | 0.73 | EGFR (0.57) | EGFRERBB2ERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6015814-A | Quinazoline derivative | ZENECA LIMITED (GB) | 2000-01-18 | — | — | US | disclosed |
| EP-0824526-A1 | QUINAZOLINE DERIVATIVE | ZENECA LIMITED (GB) | 1998-02-25 | — | — | EP | disclosed |
| WO-1996033978-A1 | QUINAZOLINE DERIVATIVE | ZENECA LIMITED (GB) | 1996-10-31 | — | — | WO | disclosed |