SCHEMBL7763005

SCHEMBL7763005

Fc1ccc(Nc2ncnc3ccc(OCCCN4CCOCC4)cc23)cc1F

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGFR P00533 14/20 0.61
ERBB2 P04626 7/20 0.61
KDR P35968 4/20 0.61
SRC P12931 4/20 0.61
BRAF P15056 2/20 0.61
CIT O14578 2/20 0.61
GAK O14976 2/20 0.61
EPHB6 O15197 2/20 0.61
RIPK2 O43353 2/20 0.61
STK17B O94768 2/20 0.61
STK10 O94804 2/20 0.61
ABL1 P00519 2/20 0.61
LCK P06239 2/20 0.61
LYN P07948 2/20 0.61
RET P07949 2/20 0.61
MET P08581 2/20 0.61
HCK P08631 2/20 0.61
FGR P09769 2/20 0.61
KIT P10721 2/20 0.61
EPHA1 P21709 2/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7766288 0.92 EGFR (0.73) EGFRERBB2KDRSRCBRAF
SCHEMBL31331907 0.86 EGFR (0.65) EGFRERBB2KDRSRCBRAF
SCHEMBL1151056 0.84 EGFR (0.82) EGFRERBB2KDRSRCBRAF
SCHEMBL8103000 0.84 EGFR (0.65) EGFRERBB2ERBB4MAPT
SCHEMBL30416288 0.84 EGFR (0.86) EGFRERBB2KDRSRCBRAF
SCHEMBL11304 0.84 EGFR (0.86) EGFRERBB2KDRSRCBRAF
Hydrochloric Acid SCHEMBL15565027 0.84 EGFR (0.81) EGFRERBB2KDRSRCBRAF
SCHEMBL7766270 0.83 EGFR (0.72) EGFRERBB2KDRSRCBRAF
SCHEMBL7770429 0.82 EGFR (0.72) EGFRERBB2KDRSRCBRAF
SCHEMBL12743373 0.81 EGFR (0.68) EGFRERBB2KDRSRCBRAF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0824525-B1 QUINAZOLINE DERIVATIVES ASTRAZENECA AB (SE) 2001-06-13 EP claimed
US-5932574-A ANTICANCER AGENT ZENECA LIMITED (GB) 1999-08-03 US claimed
EP-0824525-A1 QUINAZOLINE DERIVATIVES ZENECA LIMITED (GB) 1998-02-25 EP claimed
WO-1996033977-A1 QUINAZOLINE DERIVATIVES ZENECA LIMITED (GB) 1996-10-31 WO claimed
EP-0824525-B1 QUINAZOLINE DERIVATIVES ASTRAZENECA AB (SE) 2001-06-13 EP disclosed
US-5932574-A ANTICANCER AGENT ZENECA LIMITED (GB) 1999-08-03 US disclosed
EP-0824525-A1 QUINAZOLINE DERIVATIVES ZENECA LIMITED (GB) 1998-02-25 EP disclosed
WO-1996033977-A1 QUINAZOLINE DERIVATIVES ZENECA LIMITED (GB) 1996-10-31 WO disclosed